Effects of intracerebroventricular injection of muscimol or GABA on operant feeding in pigs

Effects of intracerebroventricular injection of muscimol or GABA on operant feeding in pigs

Young pigs were prepared with lateral intracerebroventricular (ICV) cannulae. They were housed individually in cages fitted with operant panels and could obtain food and water ad lib. The GABA-A receptor agonist muscimol (25–200 nmol) ICV produced an increase in food intake in which the dose-respons...

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Veröffentlicht in:Physiology & behavior 1990-09, Vol.48 (3), p.417-421
Hauptverfasser: Baldwin, B.A., Ebenezer, I.S., De La Riva, C.
Format: Artikel
Sprache:eng
Schlagworte:
ABSORCION DE AGUA
ABSORPTION D'EAU
ACIDE AMINE
ALIMENTACION DE LOS ANIMALES
ALIMENTATION DES ANIMAUX
AMINOACIDOS
Animals
APETITO
APPETIT
Behavioral psychophysiology
Biological and medical sciences
CERDO
COMPORTEMENT ALIMENTAIRE
Conditioning, Operant - drug effects
Dose-Response Relationship, Drug
Feeding Behavior - drug effects
Female
Food intake
Fundamental and applied biological sciences. Psychology
GABA
gamma-Aminobutyric Acid - pharmacology
HABITOS ALIMENTARIOS
Hypothalamic Area, Lateral - drug effects
INGESTION DE ALIMENTOS
Injections, Intraventricular
Intracerebroventricular injections
Male
Muscimol
Muscimol - pharmacology
Neurotransmission and behavior
Operant conditioning
Pigs
PORCIN
PRISE ALIMENTAIRE
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Receptors, GABA-A - drug effects
Swine
Ventromedial Hypothalamic Nucleus - drug effects
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Zusammenfassung:Young pigs were prepared with lateral intracerebroventricular (ICV) cannulae. They were housed individually in cages fitted with operant panels and could obtain food and water ad lib. The GABA-A receptor agonist muscimol (25–200 nmol) ICV produced an increase in food intake in which the dose-response relation was most obvious 30–60 min after dosing. The 25-nmol dose had no effect on feeding. However, muscimol (50 nmol) caused a significant increase in feeding ( p
ISSN:0031-9384
1873-507X
DOI:10.1016/0031-9384(90)90337-4