Glucocorticoid regulation of protein processing and compartmentalization

Glucocorticoid regulation of protein processing and compartmentalization

Glucocorticoids appear to regulate the post-translational processing and compartmentalization of certain proteins in cultured rat hepatoma (HTC) cells. We have found that maturation of murine mammary tumour virus (MTV) proteins in infected HTC cells is hormone-dependent. Thus, MTV gene products may...

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Veröffentlicht in:Nature (London) 1982-11, Vol.300 (5889), p.221-225
Hauptverfasser: Firestone, Gary L, Payvar, Farhang, Yamamoto, Keith R
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Compartmentation
Cell Line
Dexamethasone - pharmacology
Glycoproteins - biosynthesis
Humanities and Social Sciences
Liver Neoplasms, Experimental - metabolism
Mammary Neoplasms, Experimental - metabolism
Mammary Tumor Virus, Mouse - genetics
Mice
Molecular Weight
multidisciplinary
Mutation
Neoplasm Proteins - biosynthesis
Phosphoproteins - biosynthesis
Protein Processing, Post-Translational
Rats
Science
Science (multidisciplinary)
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Zusammenfassung:Glucocorticoids appear to regulate the post-translational processing and compartmentalization of certain proteins in cultured rat hepatoma (HTC) cells. We have found that maturation of murine mammary tumour virus (MTV) proteins in infected HTC cells is hormone-dependent. Thus, MTV gene products may represent versatile and sensitive probes for examining cellular regulation of protein maturation.
ISSN:0028-0836
1476-4687
DOI:10.1038/300221a0