Nucleotide sequence of a Ugandan HIV-1 provirus reveals genetic diversity from other HIV-1 isolates

A Ugandan isolate of human immunodeficiency virus type 1 (HIV-1), designated U455, was adapted to growth in U937 cells, the provirus cloned into the lambda L47.1 vector, and its DNA sequence determined. The sequences of some of the U455 genes showed a marked divergence from those of North American a...

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Veröffentlicht in:	AIDS research and human retroviruses 1990-09, Vol.6 (9), p.1073-1078
Hauptverfasser:	ORAM, J. D, DOWNING, R. G, ROFF, M, CLEGG, J. C. S, SERWADDA, D, CARSWELL, J. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS/HIV Amino Acid Sequence Base Sequence Biological and medical sciences DNA, Viral - chemistry Fundamental and applied biological sciences. Psychology Genetic Variation Genetics HIV-1 - genetics HIV-1 - isolation & purification Humans Male Microbiology Molecular Sequence Data Proviruses - genetics Proviruses - isolation & purification Uganda Viral Envelope Proteins - chemistry Viral Envelope Proteins - genetics Virology
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Zusammenfassung:	A Ugandan isolate of human immunodeficiency virus type 1 (HIV-1), designated U455, was adapted to growth in U937 cells, the provirus cloned into the lambda L47.1 vector, and its DNA sequence determined. The sequences of some of the U455 genes showed a marked divergence from those of North American and other African isolates. The sequenced clone was defective with single in-phase stop codons in the vpr and env genes and frame shift, resulting in a stop codon, within the vpu gene.
ISSN:	0889-2229 1931-8405
DOI:	10.1089/aid.1990.6.1073