Experimental congenital cytomegalovirus labyrinthitis and sensorineural hearing loss

Cytomegalovirus is a leading cause of human congenital viral infection and hearing loss. The pathogenesis of human congenital cytomegalovirus infection is poorly understood. We have developed a reproducible model of congenital cytomegalovirus-induced sensorineural hearing loss in guinea pigs. This r...

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Veröffentlicht in:	American journal of otolaryngology 1990-09, Vol.11 (5), p.299-303
1. Verfasser:	Woolf, Nigel K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antigens, Viral - isolation & purification Biological and medical sciences Cochlear Microphonic Potentials congenital cytomegalovirus Cytomegalovirus - immunology Cytomegalovirus Infections - complications Cytomegalovirus Infections - immunology Evoked Potentials, Auditory Female Guinea Pigs hearing loss Hearing Loss, Sensorineural - etiology Hearing Loss, Sensorineural - physiopathology Human viral diseases Infectious diseases labyrinthitis Labyrinthitis - etiology Medical sciences Viral diseases Viral diseases of the respiratory system and ent viral diseases
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Beschreibung
Zusammenfassung:	Cytomegalovirus is a leading cause of human congenital viral infection and hearing loss. The pathogenesis of human congenital cytomegalovirus infection is poorly understood. We have developed a reproducible model of congenital cytomegalovirus-induced sensorineural hearing loss in guinea pigs. This report reviews our previously published results and provides additional new information about this model.
ISSN:	0196-0709 1532-818X
DOI:	10.1016/0196-0709(90)90058-4