Persistent Cerebrospinal Fluid Leak: A Complication of the Combined Spinal-Epidural Technique

Persistent cerebrospinal fluid (CSF) leak is an apparently rare complication of dural puncture from spinal or epidural anesthesia. Combined spinal-epidural techniques are increasingly popular but persistent CSF leak has not been reported. We describe three parturients with persistent fluid leak from the insertion site after epidural catheter removal following combined spinal-epidural anesthesia. Uncertainties related to the diagnosis, treatment, and the implications of this complication are discussed, including β2-transferrin immunofixation assay as a diagnostic test for the presence of CSF in this situation.