Notch signaling: control of cell communication and cell fate

Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade present in all animal species studied to date. Notch signaling is used widely to determine cell fates and to regulate pattern formation; its dysfunction results in a tremendous variety o...

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Veröffentlicht in:	Development (Cambridge) 2004-03, Vol.131 (5), p.965-973
1. Verfasser:	Lai, Eric C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Patterning Cell Communication - physiology Drosophila - genetics Drosophila - growth & development Drosophila Proteins - genetics Drosophila Proteins - physiology Feedback Humans Membrane Proteins - genetics Membrane Proteins - physiology Models, Biological Mutation Receptors, Notch Signal Transduction
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Beschreibung
Zusammenfassung:	Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade present in all animal species studied to date. Notch signaling is used widely to determine cell fates and to regulate pattern formation; its dysfunction results in a tremendous variety of developmental defects and adult pathologies. This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns.
ISSN:	0950-1991 1477-9129
DOI:	10.1242/dev.01074