Visualization of histamine H1 receptors in dog brain by positron emission tomography

Histamine H1 receptors were visualized in the living dog brain using [11C]pyrilamine or [11C]doxepin by positron emission tomography (PET). The regional distribution of these carbon-11 labeled compounds in the brain corresponded well with that of the histamine H1 receptors separately determined by i...

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Veröffentlicht in:	Neuroscience letters 1990-10, Vol.118 (1), p.41-44
Hauptverfasser:	YANAI, K, WATANABE, T, HATAZAWA, J, ITOH, M, NUNOKI, K, HATANO, K, IWATA, R, ISHIWATA, K, IDO, T, MATSUZAWA, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - diagnostic imaging Brain - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Dogs Doxepin - metabolism Fundamental and applied biological sciences. Psychology Pyrilamine - metabolism Receptors, Histamine H1 - metabolism Tomography, Emission-Computed Triprolidine - pharmacology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Histamine H1 receptors were visualized in the living dog brain using [11C]pyrilamine or [11C]doxepin by positron emission tomography (PET). The regional distribution of these carbon-11 labeled compounds in the brain corresponded well with that of the histamine H1 receptors separately determined by in vitro binding assay. The radioactivity in the brain was reduced by treatment with triprolidine (1 mg/kg), a histamine H1 antagonist. The results of our study indicate that it is feasible to visualize histamine H1 receptors in human brain using these 11C-labeled compounds and PET.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(90)90244-4