Frequency of nonresponse antiplatelet activity of clopidogrel during pretreatment for cardiac catheterization
Platelet function was evaluated before and after clopidogrel therapy in 50 cardiology candidates scheduled for intervention; results were averaged from optical platelet aggregation with 2 significantly correlated point-of-care instruments, Thrombelastograph and Ichor PlateletWorks. Although this was...
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Veröffentlicht in: | The American journal of cardiology 2004-02, Vol.93 (4), p.456-458 |
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container_title | The American journal of cardiology |
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creator | Mobley, Joseph E. Bresee, Stuart J. Wortham, Dale C. Craft, Robert M. Snider, Carolyn C. Carroll, Roger C. |
description | Platelet function was evaluated before and after clopidogrel therapy in 50 cardiology candidates scheduled for intervention; results were averaged from optical platelet aggregation with 2 significantly correlated point-of-care instruments, Thrombelastograph and Ichor PlateletWorks. Although this was a limited study with few complications, the failure of clopidogrel therapy (30% nonresponders with |
doi_str_mv | 10.1016/j.amjcard.2003.10.042 |
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Although this was a limited study with few complications, the failure of clopidogrel therapy (30% nonresponders with <10% average platelet inhibition) was not correlated with clinical pretreatment variables, including atorvastatin therapy, postintervention bleeding complications, or major adverse coronary events.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Cardiac Catheterization</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Catheters</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Platelet Function Tests</subject><subject>Point-of-Care Systems</subject><subject>Ticlopidine - analogs & derivatives</subject><subject>Ticlopidine - pharmacology</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtrFUEQhRsxmGv0JyiDoLu59uPOayUhGA0Esonrpm93Texhpnus7gnEX2-NdyDgxlVRxVfFOXUYeyf4XnBRfx72ZhqsQbeXnCua7flBvmA70TZdKTqhXrId51yWnTh05-x1SgO1QlT1K3ZOo7qrpdyx6Rrh1wLBPhWxL0IMCGmOIUFhQvbzaDKMkAtjs3_0-S9kxzh7Fx8QxsIt6MNDMSNkBJMnCLnoIxarMG8s1fwTMqD_bbKP4Q07682Y4O1WL9iP66_3V9_L27tvN1eXt6U9iDaXQPosOClbexTKNcZ0ZNna1kqnRK_6upKdaGTDVatErch5e1AN9OLYc14pdcE-ne7OGMldynryycI4mgBxSbrlouHkn8AP_4BDXDCQNi0VV1Ujak5QdYIsxpQQej2jnww-acH1GoYe9BaGXsNYxySJ9t5vx5fjBO55a_s-AR83wCRrxh5NsD49c1WjyNjKfTlxQD979IA6WU-ZgfMINmsX_X-k_AHS0atx</recordid><startdate>20040215</startdate><enddate>20040215</enddate><creator>Mobley, Joseph E.</creator><creator>Bresee, Stuart J.</creator><creator>Wortham, Dale C.</creator><creator>Craft, Robert M.</creator><creator>Snider, Carolyn C.</creator><creator>Carroll, Roger C.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20040215</creationdate><title>Frequency of nonresponse antiplatelet activity of clopidogrel during pretreatment for cardiac catheterization</title><author>Mobley, Joseph E. ; Bresee, Stuart J. ; Wortham, Dale C. ; Craft, Robert M. ; Snider, Carolyn C. ; Carroll, Roger C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-e149ced228cb13d7aa9016cc8c2d31f3f6529172703831630428437ef1bf00533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Cardiac Catheterization</topic><topic>Cardiology. 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subjects | Adult Aged Aged, 80 and over Analysis Biological and medical sciences Blood Cardiac Catheterization Cardiology. Vascular system Cardiovascular disease Catheters Drug therapy Female Heart Humans Male Medical sciences Medical treatment Middle Aged Platelet Aggregation Inhibitors - pharmacology Platelet Function Tests Point-of-Care Systems Ticlopidine - analogs & derivatives Ticlopidine - pharmacology |
title | Frequency of nonresponse antiplatelet activity of clopidogrel during pretreatment for cardiac catheterization |
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