Effect of prostaglandin E2 on cyclic AMP levels in limb cells of mouse mutant Brachypodism
Mouse embryo limb cells carrying either the brachypodism (bpH/bpH) mutation or its wild-type (+/+) allele were tested for their ability to accumulate cyclic AMP in response to prostaglandin E2 (PGE2) between Embryonic Days E12 and E14. Mutant cells exhibited a precocious increase in cyclic AMP. In t...
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| Veröffentlicht in: | Developmental biology 1990-12, Vol.142 (2), p.489-492 |
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| container_title | Developmental biology |
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| creator | BALLARD, T. A ELMER, W. A |
| description | Mouse embryo limb cells carrying either the brachypodism (bpH/bpH) mutation or its wild-type (+/+) allele were tested for their ability to accumulate cyclic AMP in response to prostaglandin E2 (PGE2) between Embryonic Days E12 and E14. Mutant cells exhibited a precocious increase in cyclic AMP. In the absence of PGE2 but in the presence of the phosphodiesterase inhibitor 1-methyl-3-isobutylxanthine (MIX), the brachypodism cells accumulated a significantly lower amount of cyclic AMP by Day E14. Limb cells carrying the bpH mutation may provide a useful experimental system to study the PGE2-cyclic AMP-cartilage differentiation interrelationship. |
| doi_str_mv | 10.1016/0012-1606(90)90372-P |
| format | Article |
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Limb cells carrying the bpH mutation may provide a useful experimental system to study the PGE2-cyclic AMP-cartilage differentiation interrelationship.</description><identifier>ISSN: 0012-1606</identifier><identifier>EISSN: 1095-564X</identifier><identifier>DOI: 10.1016/0012-1606(90)90372-P</identifier><identifier>PMID: 1701740</identifier><identifier>CODEN: DEBIAO</identifier><language>eng</language><publisher>Amsterdam: Elsevier</publisher><subject>1-Methyl-3-isobutylxanthine - pharmacology ; Alleles ; Animals ; Biological and medical sciences ; Blastocyst - drug effects ; Blastocyst - metabolism ; Cell Differentiation ; Cyclic AMP - metabolism ; Dinoprostone - pharmacology ; Embryology: invertebrates and vertebrates. Teratology ; Experimental organogenesis ; Fundamental and applied biological sciences. Psychology ; Hindlimb - drug effects ; Hindlimb - embryology ; Hindlimb - metabolism ; Mice ; Mutation ; Organogenesis. 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A</creatorcontrib><creatorcontrib>ELMER, W. A</creatorcontrib><title>Effect of prostaglandin E2 on cyclic AMP levels in limb cells of mouse mutant Brachypodism</title><title>Developmental biology</title><addtitle>Dev Biol</addtitle><description>Mouse embryo limb cells carrying either the brachypodism (bpH/bpH) mutation or its wild-type (+/+) allele were tested for their ability to accumulate cyclic AMP in response to prostaglandin E2 (PGE2) between Embryonic Days E12 and E14. Mutant cells exhibited a precocious increase in cyclic AMP. In the absence of PGE2 but in the presence of the phosphodiesterase inhibitor 1-methyl-3-isobutylxanthine (MIX), the brachypodism cells accumulated a significantly lower amount of cyclic AMP by Day E14. Limb cells carrying the bpH mutation may provide a useful experimental system to study the PGE2-cyclic AMP-cartilage differentiation interrelationship.</description><subject>1-Methyl-3-isobutylxanthine - pharmacology</subject><subject>Alleles</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blastocyst - drug effects</subject><subject>Blastocyst - metabolism</subject><subject>Cell Differentiation</subject><subject>Cyclic AMP - metabolism</subject><subject>Dinoprostone - pharmacology</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Experimental organogenesis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hindlimb - drug effects</subject><subject>Hindlimb - embryology</subject><subject>Hindlimb - metabolism</subject><subject>Mice</subject><subject>Mutation</subject><subject>Organogenesis. 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A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-d99ab89963378f3eb917bf2f0f824407cf386eafb5d1476fc2a6f824b7e551513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>1-Methyl-3-isobutylxanthine - pharmacology</topic><topic>Alleles</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blastocyst - drug effects</topic><topic>Blastocyst - metabolism</topic><topic>Cell Differentiation</topic><topic>Cyclic AMP - metabolism</topic><topic>Dinoprostone - pharmacology</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Experimental organogenesis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hindlimb - drug effects</topic><topic>Hindlimb - embryology</topic><topic>Hindlimb - metabolism</topic><topic>Mice</topic><topic>Mutation</topic><topic>Organogenesis. Physiological fonctions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BALLARD, T. A</creatorcontrib><creatorcontrib>ELMER, W. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BALLARD, T. A</au><au>ELMER, W. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of prostaglandin E2 on cyclic AMP levels in limb cells of mouse mutant Brachypodism</atitle><jtitle>Developmental biology</jtitle><addtitle>Dev Biol</addtitle><date>1990-12-01</date><risdate>1990</risdate><volume>142</volume><issue>2</issue><spage>489</spage><epage>492</epage><pages>489-492</pages><issn>0012-1606</issn><eissn>1095-564X</eissn><coden>DEBIAO</coden><abstract>Mouse embryo limb cells carrying either the brachypodism (bpH/bpH) mutation or its wild-type (+/+) allele were tested for their ability to accumulate cyclic AMP in response to prostaglandin E2 (PGE2) between Embryonic Days E12 and E14. Mutant cells exhibited a precocious increase in cyclic AMP. In the absence of PGE2 but in the presence of the phosphodiesterase inhibitor 1-methyl-3-isobutylxanthine (MIX), the brachypodism cells accumulated a significantly lower amount of cyclic AMP by Day E14. Limb cells carrying the bpH mutation may provide a useful experimental system to study the PGE2-cyclic AMP-cartilage differentiation interrelationship.</abstract><cop>Amsterdam</cop><pub>Elsevier</pub><pmid>1701740</pmid><doi>10.1016/0012-1606(90)90372-P</doi><tpages>4</tpages></addata></record> |
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| ispartof | Developmental biology, 1990-12, Vol.142 (2), p.489-492 |
| issn | 0012-1606 1095-564X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 1-Methyl-3-isobutylxanthine - pharmacology Alleles Animals Biological and medical sciences Blastocyst - drug effects Blastocyst - metabolism Cell Differentiation Cyclic AMP - metabolism Dinoprostone - pharmacology Embryology: invertebrates and vertebrates. Teratology Experimental organogenesis Fundamental and applied biological sciences. Psychology Hindlimb - drug effects Hindlimb - embryology Hindlimb - metabolism Mice Mutation Organogenesis. Physiological fonctions |
| title | Effect of prostaglandin E2 on cyclic AMP levels in limb cells of mouse mutant Brachypodism |
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