Comparing multiple RNA secondary structures using tree comparisons

In a previous paper, an algorithm was presented for analyzing multiple RNA secondary structures utilizing a multiple string alignment algorithm. In this paper we present another approach to the problem of comparing many secondary structures by utilizing a very efficient tree-matching algorithm that...

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Veröffentlicht in:Bioinformatics 1990-10, Vol.6 (4), p.309-318
Hauptverfasser: Shapiro, Bruce A., Zhang, Kaizhong
Format: Artikel
Sprache:eng
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Zusammenfassung:In a previous paper, an algorithm was presented for analyzing multiple RNA secondary structures utilizing a multiple string alignment algorithm. In this paper we present another approach to the problem of comparing many secondary structures by utilizing a very efficient tree-matching algorithm that will compare two trees in O(|T1|×|T2|× L1 × L2) in the worst case and very close to O(|T1|×|T2|) for average trees representing secondary structures. The result of the pairwise comparison algorithm is then used with acluster algorithm to produce a multiple structure clustering which can be displayed in ataxonomy tree to show related structures.
ISSN:1367-4803
0266-7061
1460-2059
DOI:10.1093/bioinformatics/6.4.309