Comparing multiple RNA secondary structures using tree comparisons
In a previous paper, an algorithm was presented for analyzing multiple RNA secondary structures utilizing a multiple string alignment algorithm. In this paper we present another approach to the problem of comparing many secondary structures by utilizing a very efficient tree-matching algorithm that...
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Veröffentlicht in: | Bioinformatics 1990-10, Vol.6 (4), p.309-318 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | In a previous paper, an algorithm was presented for analyzing multiple RNA secondary structures utilizing a multiple string alignment algorithm. In this paper we present another approach to the problem of comparing many secondary structures by utilizing a very efficient tree-matching algorithm that will compare two trees in O(|T1|×|T2|× L1 × L2) in the worst case and very close to O(|T1|×|T2|) for average trees representing secondary structures. The result of the pairwise comparison algorithm is then used with acluster algorithm to produce a multiple structure clustering which can be displayed in ataxonomy tree to show related structures. |
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ISSN: | 1367-4803 0266-7061 1460-2059 |
DOI: | 10.1093/bioinformatics/6.4.309 |