Nucleic acid binding properties of thyminyl and adeninyl pyrrolidine-amide oligonucleotide mimics (POM)

Adeninyl POM was prepared using solid-phase peptide chemistry and shown to exhibit higher affinity for complementary DNA and RNA than the corresponding adeninyl PNA.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2004-03 (5), p.516-517
Hauptverfasser:	Tan, T H Samuel, Hickman, David T, Morral, Jordi, Beadham, Ian G, Micklefield, Jason
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - metabolism Molecular Mimicry Nucleic Acid Denaturation Nucleic Acids - metabolism Oligonucleotides - chemical synthesis Oligonucleotides - metabolism Pyrrolidines - chemical synthesis RNA - metabolism Spectrophotometry, Ultraviolet
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Beschreibung
Zusammenfassung:	Adeninyl POM was prepared using solid-phase peptide chemistry and shown to exhibit higher affinity for complementary DNA and RNA than the corresponding adeninyl PNA.
ISSN:	1359-7345
DOI:	10.1039/b315768g