UV irradiation inhibits ABC transporters via generation of ADP-ribose by concerted action of poly(ADP-ribose) polymerase-1 and glycohydrolase
ATP-binding cassette (ABC) transporters are involved in the transport of multiple substrates across cellular membranes, including metabolites, proteins, and drugs. Employing a functional fluorochrome export assay, we found that UVB irradiation strongly inhibits the activity of ABC transporters. Spec...
Gespeichert in:
| Veröffentlicht in: | Cell death and differentiation 2004-03, Vol.11 (3), p.314-320 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 320 |
|---|---|
| container_issue | 3 |
| container_start_page | 314 |
| container_title | Cell death and differentiation |
| container_volume | 11 |
| creator | Dumitriu, I E Voll, R E Kolowos, W Gaipl, U S Heyder, P Kalden, J R Herrmann, M |
| description | ATP-binding cassette (ABC) transporters are involved in the transport of multiple substrates across cellular membranes, including metabolites, proteins, and drugs. Employing a functional fluorochrome export assay, we found that UVB irradiation strongly inhibits the activity of ABC transporters. Specific inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) restored the function of ABC transporters in UVB-irradiated cells, and PARP-1-deficient cells did not undergo UVB-induced membrane transport inhibition. These data suggest that PARP-1 activation is necessary for ABC transporter functional downregulation. The hydrolysis of poly(ADP-ribose) by poly(ADP-ribose) glycohydrolase (PARG) was also required, since specific PARG inhibitors, which limit the production of ADP-ribose molecules, restored the function of ABC transporters. Furthermore, ADP-ribose molecules potently inhibited the activity of the ABC transporter P-glycoprotein. Hence, poly(ADP-ribose) metabolism appears to play a novel role in the regulation of ABC transporters. |
| doi_str_mv | 10.1038/sj.cdd.4401348 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80159772</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17912760</sourcerecordid><originalsourceid>FETCH-LOGICAL-c429t-ab14fba36d5dfa0379cc77a310cbd268902b695afc11abe8e850c939537ac1513</originalsourceid><addsrcrecordid>eNqF0U1rFDEYB_AgFlurV48SPIgeZptnkkwmx3V9hYIerNeQt9lmmU3WZFaYD9HvbHRXFgrSU8KTX_4h_BF6AWQBhPZXZbOwzi0YI0BZ_whdABNdwxmhj-uectJIwsQ5elrKhhDSCdk9QefAup4DFxfo7uYHDjlrF_QUUsQh3gYTpoKX71Z4yjqWXcqTzwX_ChqvffT5ANOAl--_NTmYVDw2M7YpWl-pw9r-E7s0zm9O7O3fwbZGFN8A1tHh9TjbdDu7nMY6fIbOBj0W__y4XqKbjx--rz43118_fVktrxvLWjk12gAbjKad427QhApprRCaArHGtV0vSWs6yfVgAbTxve85sZJKToW2wIFeoteH3F1OP_e-TGobivXjqKNP-6J6AlwK0T4IQUhoRUcqfHUPbtI-x_oJ1YIQDGTPKlockM2plOwHtcthq_OsgKg_daqyUbVOdayzXnh5TN2brXcnfuyvgqsDKPUorn0-PfufyN8BOKzG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>217741984</pqid></control><display><type>article</type><title>UV irradiation inhibits ABC transporters via generation of ADP-ribose by concerted action of poly(ADP-ribose) polymerase-1 and glycohydrolase</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Dumitriu, I E ; Voll, R E ; Kolowos, W ; Gaipl, U S ; Heyder, P ; Kalden, J R ; Herrmann, M</creator><creatorcontrib>Dumitriu, I E ; Voll, R E ; Kolowos, W ; Gaipl, U S ; Heyder, P ; Kalden, J R ; Herrmann, M</creatorcontrib><description>ATP-binding cassette (ABC) transporters are involved in the transport of multiple substrates across cellular membranes, including metabolites, proteins, and drugs. Employing a functional fluorochrome export assay, we found that UVB irradiation strongly inhibits the activity of ABC transporters. Specific inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) restored the function of ABC transporters in UVB-irradiated cells, and PARP-1-deficient cells did not undergo UVB-induced membrane transport inhibition. These data suggest that PARP-1 activation is necessary for ABC transporter functional downregulation. The hydrolysis of poly(ADP-ribose) by poly(ADP-ribose) glycohydrolase (PARG) was also required, since specific PARG inhibitors, which limit the production of ADP-ribose molecules, restored the function of ABC transporters. Furthermore, ADP-ribose molecules potently inhibited the activity of the ABC transporter P-glycoprotein. Hence, poly(ADP-ribose) metabolism appears to play a novel role in the regulation of ABC transporters.</description><identifier>ISSN: 1350-9047</identifier><identifier>EISSN: 1476-5403</identifier><identifier>DOI: 10.1038/sj.cdd.4401348</identifier><identifier>PMID: 14685157</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>ABC transporters ; Adenosine Diphosphate Ribose - biosynthesis ; Adenosine Triphosphate - analysis ; Animals ; Apoptosis ; ATP-Binding Cassette Transporters - antagonists & inhibitors ; ATP-Binding Cassette Transporters - drug effects ; ATP-Binding Cassette Transporters - metabolism ; ATP-Binding Cassette Transporters - radiation effects ; Biochemistry ; Biological Transport, Active - radiation effects ; Biomedical and Life Sciences ; Cell Biology ; Cell Cycle Analysis ; Cell death ; Cells, Cultured ; Drug dosages ; Fluorescent Dyes - metabolism ; Glycoside Hydrolases - genetics ; Glycoside Hydrolases - metabolism ; Granulocytes - cytology ; Granulocytes - metabolism ; Humans ; Hydrolyzable Tannins - pharmacology ; Immunology ; Internal medicine ; Leukocytes, Mononuclear - cytology ; Leukocytes, Mononuclear - metabolism ; Life Sciences ; Lymphocytes ; Membranes ; Metabolites ; Mice ; Mice, Knockout ; Models, Biological ; original-paper ; Poly(ADP-ribose) Polymerases - genetics ; Poly(ADP-ribose) Polymerases - metabolism ; Proteins ; Stem Cells ; Temperature ; Ultraviolet Rays</subject><ispartof>Cell death and differentiation, 2004-03, Vol.11 (3), p.314-320</ispartof><rights>Springer Nature Limited 2004</rights><rights>Copyright Nature Publishing Group Mar 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-ab14fba36d5dfa0379cc77a310cbd268902b695afc11abe8e850c939537ac1513</citedby><cites>FETCH-LOGICAL-c429t-ab14fba36d5dfa0379cc77a310cbd268902b695afc11abe8e850c939537ac1513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.cdd.4401348$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.cdd.4401348$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14685157$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dumitriu, I E</creatorcontrib><creatorcontrib>Voll, R E</creatorcontrib><creatorcontrib>Kolowos, W</creatorcontrib><creatorcontrib>Gaipl, U S</creatorcontrib><creatorcontrib>Heyder, P</creatorcontrib><creatorcontrib>Kalden, J R</creatorcontrib><creatorcontrib>Herrmann, M</creatorcontrib><title>UV irradiation inhibits ABC transporters via generation of ADP-ribose by concerted action of poly(ADP-ribose) polymerase-1 and glycohydrolase</title><title>Cell death and differentiation</title><addtitle>Cell Death Differ</addtitle><addtitle>Cell Death Differ</addtitle><description>ATP-binding cassette (ABC) transporters are involved in the transport of multiple substrates across cellular membranes, including metabolites, proteins, and drugs. Employing a functional fluorochrome export assay, we found that UVB irradiation strongly inhibits the activity of ABC transporters. Specific inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) restored the function of ABC transporters in UVB-irradiated cells, and PARP-1-deficient cells did not undergo UVB-induced membrane transport inhibition. These data suggest that PARP-1 activation is necessary for ABC transporter functional downregulation. The hydrolysis of poly(ADP-ribose) by poly(ADP-ribose) glycohydrolase (PARG) was also required, since specific PARG inhibitors, which limit the production of ADP-ribose molecules, restored the function of ABC transporters. Furthermore, ADP-ribose molecules potently inhibited the activity of the ABC transporter P-glycoprotein. Hence, poly(ADP-ribose) metabolism appears to play a novel role in the regulation of ABC transporters.</description><subject>ABC transporters</subject><subject>Adenosine Diphosphate Ribose - biosynthesis</subject><subject>Adenosine Triphosphate - analysis</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>ATP-Binding Cassette Transporters - antagonists & inhibitors</subject><subject>ATP-Binding Cassette Transporters - drug effects</subject><subject>ATP-Binding Cassette Transporters - metabolism</subject><subject>ATP-Binding Cassette Transporters - radiation effects</subject><subject>Biochemistry</subject><subject>Biological Transport, Active - radiation effects</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Cell Cycle Analysis</subject><subject>Cell death</subject><subject>Cells, Cultured</subject><subject>Drug dosages</subject><subject>Fluorescent Dyes - metabolism</subject><subject>Glycoside Hydrolases - genetics</subject><subject>Glycoside Hydrolases - metabolism</subject><subject>Granulocytes - cytology</subject><subject>Granulocytes - metabolism</subject><subject>Humans</subject><subject>Hydrolyzable Tannins - pharmacology</subject><subject>Immunology</subject><subject>Internal medicine</subject><subject>Leukocytes, Mononuclear - cytology</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Life Sciences</subject><subject>Lymphocytes</subject><subject>Membranes</subject><subject>Metabolites</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Models, Biological</subject><subject>original-paper</subject><subject>Poly(ADP-ribose) Polymerases - genetics</subject><subject>Poly(ADP-ribose) Polymerases - metabolism</subject><subject>Proteins</subject><subject>Stem Cells</subject><subject>Temperature</subject><subject>Ultraviolet Rays</subject><issn>1350-9047</issn><issn>1476-5403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0U1rFDEYB_AgFlurV48SPIgeZptnkkwmx3V9hYIerNeQt9lmmU3WZFaYD9HvbHRXFgrSU8KTX_4h_BF6AWQBhPZXZbOwzi0YI0BZ_whdABNdwxmhj-uectJIwsQ5elrKhhDSCdk9QefAup4DFxfo7uYHDjlrF_QUUsQh3gYTpoKX71Z4yjqWXcqTzwX_ChqvffT5ANOAl--_NTmYVDw2M7YpWl-pw9r-E7s0zm9O7O3fwbZGFN8A1tHh9TjbdDu7nMY6fIbOBj0W__y4XqKbjx--rz43118_fVktrxvLWjk12gAbjKad427QhApprRCaArHGtV0vSWs6yfVgAbTxve85sZJKToW2wIFeoteH3F1OP_e-TGobivXjqKNP-6J6AlwK0T4IQUhoRUcqfHUPbtI-x_oJ1YIQDGTPKlockM2plOwHtcthq_OsgKg_daqyUbVOdayzXnh5TN2brXcnfuyvgqsDKPUorn0-PfufyN8BOKzG</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Dumitriu, I E</creator><creator>Voll, R E</creator><creator>Kolowos, W</creator><creator>Gaipl, U S</creator><creator>Heyder, P</creator><creator>Kalden, J R</creator><creator>Herrmann, M</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>UV irradiation inhibits ABC transporters via generation of ADP-ribose by concerted action of poly(ADP-ribose) polymerase-1 and glycohydrolase</title><author>Dumitriu, I E ; Voll, R E ; Kolowos, W ; Gaipl, U S ; Heyder, P ; Kalden, J R ; Herrmann, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-ab14fba36d5dfa0379cc77a310cbd268902b695afc11abe8e850c939537ac1513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>ABC transporters</topic><topic>Adenosine Diphosphate Ribose - biosynthesis</topic><topic>Adenosine Triphosphate - analysis</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>ATP-Binding Cassette Transporters - antagonists & inhibitors</topic><topic>ATP-Binding Cassette Transporters - drug effects</topic><topic>ATP-Binding Cassette Transporters - metabolism</topic><topic>ATP-Binding Cassette Transporters - radiation effects</topic><topic>Biochemistry</topic><topic>Biological Transport, Active - radiation effects</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Cell Cycle Analysis</topic><topic>Cell death</topic><topic>Cells, Cultured</topic><topic>Drug dosages</topic><topic>Fluorescent Dyes - metabolism</topic><topic>Glycoside Hydrolases - genetics</topic><topic>Glycoside Hydrolases - metabolism</topic><topic>Granulocytes - cytology</topic><topic>Granulocytes - metabolism</topic><topic>Humans</topic><topic>Hydrolyzable Tannins - pharmacology</topic><topic>Immunology</topic><topic>Internal medicine</topic><topic>Leukocytes, Mononuclear - cytology</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Life Sciences</topic><topic>Lymphocytes</topic><topic>Membranes</topic><topic>Metabolites</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Models, Biological</topic><topic>original-paper</topic><topic>Poly(ADP-ribose) Polymerases - genetics</topic><topic>Poly(ADP-ribose) Polymerases - metabolism</topic><topic>Proteins</topic><topic>Stem Cells</topic><topic>Temperature</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dumitriu, I E</creatorcontrib><creatorcontrib>Voll, R E</creatorcontrib><creatorcontrib>Kolowos, W</creatorcontrib><creatorcontrib>Gaipl, U S</creatorcontrib><creatorcontrib>Heyder, P</creatorcontrib><creatorcontrib>Kalden, J R</creatorcontrib><creatorcontrib>Herrmann, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell death and differentiation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dumitriu, I E</au><au>Voll, R E</au><au>Kolowos, W</au><au>Gaipl, U S</au><au>Heyder, P</au><au>Kalden, J R</au><au>Herrmann, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>UV irradiation inhibits ABC transporters via generation of ADP-ribose by concerted action of poly(ADP-ribose) polymerase-1 and glycohydrolase</atitle><jtitle>Cell death and differentiation</jtitle><stitle>Cell Death Differ</stitle><addtitle>Cell Death Differ</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>11</volume><issue>3</issue><spage>314</spage><epage>320</epage><pages>314-320</pages><issn>1350-9047</issn><eissn>1476-5403</eissn><abstract>ATP-binding cassette (ABC) transporters are involved in the transport of multiple substrates across cellular membranes, including metabolites, proteins, and drugs. Employing a functional fluorochrome export assay, we found that UVB irradiation strongly inhibits the activity of ABC transporters. Specific inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) restored the function of ABC transporters in UVB-irradiated cells, and PARP-1-deficient cells did not undergo UVB-induced membrane transport inhibition. These data suggest that PARP-1 activation is necessary for ABC transporter functional downregulation. The hydrolysis of poly(ADP-ribose) by poly(ADP-ribose) glycohydrolase (PARG) was also required, since specific PARG inhibitors, which limit the production of ADP-ribose molecules, restored the function of ABC transporters. Furthermore, ADP-ribose molecules potently inhibited the activity of the ABC transporter P-glycoprotein. Hence, poly(ADP-ribose) metabolism appears to play a novel role in the regulation of ABC transporters.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>14685157</pmid><doi>10.1038/sj.cdd.4401348</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1350-9047 |
| ispartof | Cell death and differentiation, 2004-03, Vol.11 (3), p.314-320 |
| issn | 1350-9047 1476-5403 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80159772 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | ABC transporters Adenosine Diphosphate Ribose - biosynthesis Adenosine Triphosphate - analysis Animals Apoptosis ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - drug effects ATP-Binding Cassette Transporters - metabolism ATP-Binding Cassette Transporters - radiation effects Biochemistry Biological Transport, Active - radiation effects Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell death Cells, Cultured Drug dosages Fluorescent Dyes - metabolism Glycoside Hydrolases - genetics Glycoside Hydrolases - metabolism Granulocytes - cytology Granulocytes - metabolism Humans Hydrolyzable Tannins - pharmacology Immunology Internal medicine Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - metabolism Life Sciences Lymphocytes Membranes Metabolites Mice Mice, Knockout Models, Biological original-paper Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Proteins Stem Cells Temperature Ultraviolet Rays |
| title | UV irradiation inhibits ABC transporters via generation of ADP-ribose by concerted action of poly(ADP-ribose) polymerase-1 and glycohydrolase |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T11%3A06%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=UV%20irradiation%20inhibits%20ABC%20transporters%20via%20generation%20of%20ADP-ribose%20by%20concerted%20action%20of%20poly(ADP-ribose)%20polymerase-1%20and%20glycohydrolase&rft.jtitle=Cell%20death%20and%20differentiation&rft.au=Dumitriu,%20I%20E&rft.date=2004-03-01&rft.volume=11&rft.issue=3&rft.spage=314&rft.epage=320&rft.pages=314-320&rft.issn=1350-9047&rft.eissn=1476-5403&rft_id=info:doi/10.1038/sj.cdd.4401348&rft_dat=%3Cproquest_cross%3E17912760%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=217741984&rft_id=info:pmid/14685157&rfr_iscdi=true |