A General, Selective, High-Yield N-Demethylation Procedure for Tertiary Amines by Solid Reagents in a Convenient Column Chromatography-like Setup
A traditional preparative chromatographic column can be used to achieve quantitative N-demethylation of tertiary N-methylamines and alkaloids. The filling is the crucial part and is loaded with different solid reagents in three reaction zones. The parent compound is charged on the column, and the ne...
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| Veröffentlicht in: | Organic letters 2004-02, Vol.6 (4), p.541-544 |
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| container_title | Organic letters |
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| creator | Rosenau, Thomas Hofinger, Andreas Potthast, Antje Kosma, Paul |
| description | A traditional preparative chromatographic column can be used to achieve quantitative N-demethylation of tertiary N-methylamines and alkaloids. The filling is the crucial part and is loaded with different solid reagents in three reaction zones. The parent compound is charged on the column, and the neat N-demethylated secondary amine leaves the column some minutes later. |
| doi_str_mv | 10.1021/ol036319g |
| format | Article |
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The parent compound is charged on the column, and the neat N-demethylated secondary amine leaves the column some minutes later.</description><subject>Alkaloids - chemistry</subject><subject>Chromatography</subject><subject>Indicators and Reagents</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Methylamines - chemistry</subject><subject>Methylation</subject><subject>Molecular Structure</subject><subject>Oxidation-Reduction</subject><issn>1523-7060</issn><issn>1523-7052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEFrGzEUhEVIadK0h_6BoksKhWyrp12vVkfjtkkhNKFJDzktsvTWVqKVHEkb8M_oP66KTXLp6Q3Dx_BmCHkP7DMwDl-CY3Vbg1wdkGOY8boSbMYPn3XLjsiblO4Zg-LI1-QIGtlCC90x-TOn5-gxKndGb9ChzvYJz-iFXa2rO4vO0J_VVxwxr7dOZRs8vY5Bo5ki0iFEeosxWxW3dD5aj4kut_QmOGvoL1Qr9DlR66mii-Cf0NtiFOmm0dPFOoZR5bCKarPeVs4-YHkgT5u35NWgXMJ3-3tCfn__dru4qC6vzn8s5peVqgFyJWvTdWopmJZMt0YCNhykaoXRYlC6QS24YA1vB84axlGKBsoqgncMpTamPiEfd7mbGB4nTLkfbdLonPIYptR3DGad4FDATztQx5BSxKHfRDuWzj2w_t_-_fP-hf2wD52WI5oXcj94AU53gNKpvw9T9KXjf4L-AkMijOY</recordid><startdate>20040219</startdate><enddate>20040219</enddate><creator>Rosenau, Thomas</creator><creator>Hofinger, Andreas</creator><creator>Potthast, Antje</creator><creator>Kosma, Paul</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040219</creationdate><title>A General, Selective, High-Yield N-Demethylation Procedure for Tertiary Amines by Solid Reagents in a Convenient Column Chromatography-like Setup</title><author>Rosenau, Thomas ; Hofinger, Andreas ; Potthast, Antje ; Kosma, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a311t-93d88ab70c90c6d91e4219a67dc7fac4ec7270426f20402e97410527280e9cdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Alkaloids - chemistry</topic><topic>Chromatography</topic><topic>Indicators and Reagents</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Methylamines - chemistry</topic><topic>Methylation</topic><topic>Molecular Structure</topic><topic>Oxidation-Reduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosenau, Thomas</creatorcontrib><creatorcontrib>Hofinger, Andreas</creatorcontrib><creatorcontrib>Potthast, Antje</creatorcontrib><creatorcontrib>Kosma, Paul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Organic letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosenau, Thomas</au><au>Hofinger, Andreas</au><au>Potthast, Antje</au><au>Kosma, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A General, Selective, High-Yield N-Demethylation Procedure for Tertiary Amines by Solid Reagents in a Convenient Column Chromatography-like Setup</atitle><jtitle>Organic letters</jtitle><addtitle>Org. 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| ispartof | Organic letters, 2004-02, Vol.6 (4), p.541-544 |
| issn | 1523-7060 1523-7052 |
| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Alkaloids - chemistry Chromatography Indicators and Reagents Magnetic Resonance Spectroscopy Methylamines - chemistry Methylation Molecular Structure Oxidation-Reduction |
| title | A General, Selective, High-Yield N-Demethylation Procedure for Tertiary Amines by Solid Reagents in a Convenient Column Chromatography-like Setup |
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