A General, Selective, High-Yield N-Demethylation Procedure for Tertiary Amines by Solid Reagents in a Convenient Column Chromatography-like Setup

A General, Selective, High-Yield N-Demethylation Procedure for Tertiary Amines by Solid Reagents in a Convenient Column Chromatography-like Setup

A traditional preparative chromatographic column can be used to achieve quantitative N-demethylation of tertiary N-methylamines and alkaloids. The filling is the crucial part and is loaded with different solid reagents in three reaction zones. The parent compound is charged on the column, and the ne...

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Veröffentlicht in:Organic letters 2004-02, Vol.6 (4), p.541-544
Hauptverfasser: Rosenau, Thomas, Hofinger, Andreas, Potthast, Antje, Kosma, Paul
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids - chemistry
Chromatography
Indicators and Reagents
Magnetic Resonance Spectroscopy
Methylamines - chemistry
Methylation
Molecular Structure
Oxidation-Reduction
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Zusammenfassung:A traditional preparative chromatographic column can be used to achieve quantitative N-demethylation of tertiary N-methylamines and alkaloids. The filling is the crucial part and is loaded with different solid reagents in three reaction zones. The parent compound is charged on the column, and the neat N-demethylated secondary amine leaves the column some minutes later.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol036319g