Expression of epstein‐barr virus‐encoded proteins and B‐cell markers in fatal infectious mononucleosis

We assessed 33 lymphoid tissues from 15 patients, including 7 with X‐linked lymphoproliferative disease (XLP) and 8 pa tients with sporadic fatal infectious mononucleosis (IM), to determine whether the cellular infiltrate had the immu nophenotype and expressed Epstein‐Barr virus (EBV)‐encoded protei...

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Veröffentlicht in:	International journal of cancer 1990-12, Vol.46 (6), p.976-984
Hauptverfasser:	Falk, Kerstin, Ernberg, Ingemar, Sakthivel, Ramasamy, Davis, Jack, Christensson, Birger, Luka, Janos, Okano, Motohiko, Grierson, Helen L., Klein, George, Purtilo, David T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens, Viral - analysis B-Lymphocytes - immunology B-Lymphocytes - microbiology Blotting, Southern Cell Line Child Child, Preschool DNA, Viral - analysis Epstein-Barr Virus Nuclear Antigens Herpesvirus 4, Human - genetics Humans Immunoblotting Immunophenotyping Infant Infectious Mononucleosis - immunology Lymphoproliferative Disorders - genetics Lymphoproliferative Disorders - immunology Lymphoproliferative Disorders - microbiology Viral Proteins - biosynthesis
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Zusammenfassung:	We assessed 33 lymphoid tissues from 15 patients, including 7 with X‐linked lymphoproliferative disease (XLP) and 8 pa tients with sporadic fatal infectious mononucleosis (IM), to determine whether the cellular infiltrate had the immu nophenotype and expressed Epstein‐Barr virus (EBV)‐encoded proteins characteristic of either EBV‐immortalized lymphoblastoid cell lines (LCL) or EBV‐carrying Burkitt lymphoma (BL) cells. The results of these studies revealed that in 13 cases the proliferating B cells were polyclonal, LCL‐like, and in 2 cases they were monoclonal, malignant lymphomalike.
ISSN:	0020-7136 1097-0215
DOI:	10.1002/ijc.2910460605