Transferrin's Mechanism of Interaction with Receptor 1

The kinetics and thermodynamics of the interactions of transferrin receptor 1 with holotransferrin and apotransferrin in neutral and mildly acidic media are investigated at 37 °C in the presence of CHAPS micelles. Receptor 1 interacts with CHAPS in a very fast kinetic step (

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Bibliographische Detailangaben
Veröffentlicht in:	Biochemistry (Easton) 2004-02, Vol.43 (6), p.1736-1745
Hauptverfasser:	Hémadi, Miryana, Kahn, Philippe H, Miquel, Geneviève, El Hage Chahine, Jean-Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD Apoproteins - chemistry Apoproteins - metabolism Cholic Acids - chemistry Detergents - chemistry Endosomes - chemistry Endosomes - metabolism Humans Hydrogen-Ion Concentration Kinetics Models, Chemical Pregnancy Proteins - chemistry Pregnancy Proteins - metabolism Receptors, Transferrin - chemistry Receptors, Transferrin - metabolism Solutions Spectrometry, Fluorescence Spectrophotometry Thermodynamics Transferrin - chemistry Transferrin - metabolism
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Beschreibung
Zusammenfassung:	The kinetics and thermodynamics of the interactions of transferrin receptor 1 with holotransferrin and apotransferrin in neutral and mildly acidic media are investigated at 37 °C in the presence of CHAPS micelles. Receptor 1 interacts with CHAPS in a very fast kinetic step (
ISSN:	0006-2960 1520-4995
DOI:	10.1021/bi030142g