First total synthesis of murisolin

First total synthesis of murisolin

The first and concise total synthesis of murisolin (1) was accomplished using asymmetric alkynylation and Sonogashira coupling as the key steps. The threo/trans/threo-type THF ring moiety was constructed with excellent stereoselectivity by asymmetric alkynylation of 1,6-heptadiyne to alpha-tetrahydr...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2004-02 (4), p.406-407
Hauptverfasser: Maezaki, Naoyoshi, Tominaga, Hiroaki, Kojima, Naoto, Yanai, Minori, Urabe, Daisuke, Tanaka, Tetsuaki
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container_end_page 407
container_issue 4
container_start_page 406
container_title Chemical communications (Cambridge, England)
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creator Maezaki, Naoyoshi
Tominaga, Hiroaki
Kojima, Naoto
Yanai, Minori
Urabe, Daisuke
Tanaka, Tetsuaki
description The first and concise total synthesis of murisolin (1) was accomplished using asymmetric alkynylation and Sonogashira coupling as the key steps. The threo/trans/threo-type THF ring moiety was constructed with excellent stereoselectivity by asymmetric alkynylation of 1,6-heptadiyne to alpha-tetrahydrofuranic aldehyde, which was also prepared via the asymmetric alkynylation.
doi_str_mv 10.1039/b312362f
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title First total synthesis of murisolin
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