First total synthesis of murisolin

First total synthesis of murisolin

The first and concise total synthesis of murisolin (1) was accomplished using asymmetric alkynylation and Sonogashira coupling as the key steps. The threo/trans/threo-type THF ring moiety was constructed with excellent stereoselectivity by asymmetric alkynylation of 1,6-heptadiyne to alpha-tetrahydr...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2004-02 (4), p.406-407
Hauptverfasser: Maezaki, Naoyoshi, Tominaga, Hiroaki, Kojima, Naoto, Yanai, Minori, Urabe, Daisuke, Tanaka, Tetsuaki
Format: Artikel
Sprache:eng
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Zusammenfassung:The first and concise total synthesis of murisolin (1) was accomplished using asymmetric alkynylation and Sonogashira coupling as the key steps. The threo/trans/threo-type THF ring moiety was constructed with excellent stereoselectivity by asymmetric alkynylation of 1,6-heptadiyne to alpha-tetrahydrofuranic aldehyde, which was also prepared via the asymmetric alkynylation.
ISSN:1359-7345
DOI:10.1039/b312362f