Central role of the P2Y12 receptor in platelet activation

Platelet activation occurs in response to vessel injury and is important for the arrest of bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic damage. The P2Y(12) receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y...

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Veröffentlicht in:	The Journal of clinical investigation 2004-02, Vol.113 (3), p.340-345
Hauptverfasser:	Dorsam, Robert T, Kunapuli, Satya P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - metabolism Bleeding Time Blood Coagulation - physiology Blood Platelets - metabolism Humans Membrane Proteins - metabolism Platelet Activation - physiology Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2Y12
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Beschreibung
Zusammenfassung:	Platelet activation occurs in response to vessel injury and is important for the arrest of bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic damage. The P2Y(12) receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y(12) receptor antagonists that have proven therapeutic value.
ISSN:	0021-9738
DOI:	10.1172/JCI20986