Monitoring p53's pulse

Monitoring p53's pulse

The tumor-suppressor protein p53 mediates the response of mammalian cells to DNA damage. Studies now show that DNA damage elicits quantal pulses of p53, with greater damage eliciting more pulses.

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Bibliographische Detailangaben
Veröffentlicht in:Nature genetics 2004-02, Vol.36 (2), p.113-114
1. Verfasser: Tyson, John J
Format: Artikel
Sprache:eng
Schlagworte:
Agriculture
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Biomedicine
Cancer Research
Causes of
DNA damage
DNA Damage - physiology
Gene Function
Human Genetics
Humans
news-and-views
Physiological aspects
Tumor suppressor genes
Tumor Suppressor Protein p53 - physiology
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Beschreibung
Zusammenfassung:The tumor-suppressor protein p53 mediates the response of mammalian cells to DNA damage. Studies now show that DNA damage elicits quantal pulses of p53, with greater damage eliciting more pulses.
ISSN:1061-4036
1546-1718
DOI:10.1038/ng0204-113