NMDA-dependent induction of long-term potentiation in afferent and association fiber systems of piriform cortex in vitro

Long-term potentiation (LTP) was demonstrated in a slice preparation of piriform (olfactory) cortex. LTP could be reliably induced in both afferent and association fiber pathways. The magnitude of the observed potentiation was greater in the association fiber pathway. 2-Amino-5-phosphonovalerate (AP...

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Veröffentlicht in:	Brain research 1990-08, Vol.525 (1), p.175-179
Hauptverfasser:	Kanter, Evan D., Haberly, Lewis B.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-5-phosphonovalerate - pharmacology Afferent Pathways - physiology Animals Cerebral Cortex - physiology Electric Stimulation Evoked Potentials - physiology In Vitro Techniques Long-term potentiation N-methyl- d-aspartate Nerve Fibers - physiology Olfaction Piriform cortex Rats Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - physiology Synaptic plasticity Time Factors
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Zusammenfassung:	Long-term potentiation (LTP) was demonstrated in a slice preparation of piriform (olfactory) cortex. LTP could be reliably induced in both afferent and association fiber pathways. The magnitude of the observed potentiation was greater in the association fiber pathway. 2-Amino-5-phosphonovalerate (APV) blocked induction of LTP in both pathways, indicating thatN-methyl- d-aspartate (NMDA) receptor activation is required for induction.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(90)91337-G