Angiocentric immunoproliferative lesion/T‐cell non‐Hodgkin's lymphoma and the acquired immune deficiency syndrome: A case report and review of the literature

The lesions known as lymphocytic vasculitis, polymorphic reticulosis (midline malignant reticulosis, lethal midline granuloma), lymphomatoid granulomatosis, and angiocentric lymphoma form what have been collectively termed the angiocentric immunoproliferative lesions (AIL). Because of recent reports demonstrating clonal rearrangements of the T‐cell receptor in these lesions, the AIL are now thought to represent a continuous spectrum of post‐thymic T‐cell non‐Hodgkin's lymphoma (NHL). NHL associated with the acquired immune deficiency syndrome (AIDS) represents intermediate or high‐grade B‐cell malignancies in HIV‐infected patients that may be etiologically related to the Epstein‐Barr virus (EBV). There have been reports of EBV‐associated T‐cell NHL, AlL, and large granular lymphocyte (LGL) proliferations, as well as HIV‐associated T‐cell neoplasia, LGL/T‐cell proliferations, and AIL. We describe a case of polymorphic reticulosis (lethal midline granuloma) arising in an HIV‐infected individual, who later progressed to AIDS, and review the literature on HIV‐associated and EBV‐associated T‐cell neoplasia, LGL/T‐cell proliferations, and AIL. the etiology of this AIL/T‐cell NHL, especially in relation to EBV and HIV, is discussed.