Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases

We studied the effects of oral administration of sodium salicylate on the expression of the pro-inflammatory mediators, nitric oxide synthase (iNOS) and cyclooxygenase- (COX-) 1 and 2, in rats with experimental autoimmune encephalomyelitis (EAE). Sodium salicylate (200 mg/kg) was administered orally...

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Veröffentlicht in:	Neuroscience letters 2004-02, Vol.356 (2), p.123-126
Hauptverfasser:	Moon, Changjong, Ahn, Meejung, Jee, Youngheun, Heo, Seungdam, Kim, Seungjoon, Kim, Hyungmin, Sim, Ki-Bum, Koh, Chang-Sung, Shin, Young-Gyun, Shin, Taekyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Blotting, Western Cerebrospinal fluid. Meninges. Spinal cord Cyclooxygenase Cyclooxygenase Inhibitors - administration & dosage Cyclooxygenase Inhibitors - pharmacology Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - enzymology Fundamental and applied biological sciences. Psychology Immunohistochemistry Male Medical sciences Nervous system (semeiology, syndromes) Neurology Nitric oxide synthase Nitric Oxide Synthase - drug effects Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Prostaglandin-Endoperoxide Synthases - drug effects Prostaglandin-Endoperoxide Synthases - metabolism Rats Rats, Inbred Lew Sodium salicylate Sodium Salicylate - administration & dosage Sodium Salicylate - pharmacology Spinal Cord - drug effects Spinal Cord - metabolism Spinal Cord - pathology Vertebrates: nervous system and sense organs
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Zusammenfassung:	We studied the effects of oral administration of sodium salicylate on the expression of the pro-inflammatory mediators, nitric oxide synthase (iNOS) and cyclooxygenase- (COX-) 1 and 2, in rats with experimental autoimmune encephalomyelitis (EAE). Sodium salicylate (200 mg/kg) was administered orally for 13 days after the induction of EAE by immunization with guinea pig myelin basic protein and complete Freund's adjuvant. The onset ( P
ISSN:	0304-3940 1872-7972
DOI:	10.1016/j.neulet.2003.11.038