Direct Synthesis of Sulfonamides and Activated Sulfonate Esters from Sulfonic Acids

Direct Synthesis of Sulfonamides and Activated Sulfonate Esters from Sulfonic Acids

A general new method for the preparation of sulfonamides and activated sulfonate esters by the direct coupling of sulfonic acid salts with amines and alcohols using the reagent triphenylphosphine ditriflate is described. A new reusable polymer-supported reagent for these transformations under hetero...

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Veröffentlicht in:Journal of the American Chemical Society 2004-02, Vol.126 (4), p.1024-1025
Hauptverfasser: Caddick, Stephen, Wilden, Jonathan D, Judd, Duncan B
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Esters - chemistry
Exact sciences and technology
Mesylates - chemistry
Organic chemistry
Organophosphorus Compounds - chemistry
Sulfonamides - chemical synthesis
Sulfonic Acids - chemistry
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container_issue 4
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container_title Journal of the American Chemical Society
container_volume 126
creator Caddick, Stephen
Wilden, Jonathan D
Judd, Duncan B
description A general new method for the preparation of sulfonamides and activated sulfonate esters by the direct coupling of sulfonic acid salts with amines and alcohols using the reagent triphenylphosphine ditriflate is described. A new reusable polymer-supported reagent for these transformations under heterogeneous conditions is also described. These methods provide a fundamentally new approach to making small molecules containing the sulfonamide functional group.
doi_str_mv 10.1021/ja0397658
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source ACS Publications; MEDLINE
subjects Chemistry
Esters - chemistry
Exact sciences and technology
Mesylates - chemistry
Organic chemistry
Organophosphorus Compounds - chemistry
Sulfonamides - chemical synthesis
Sulfonic Acids - chemistry
title Direct Synthesis of Sulfonamides and Activated Sulfonate Esters from Sulfonic Acids
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