Direct Synthesis of Sulfonamides and Activated Sulfonate Esters from Sulfonic Acids

Direct Synthesis of Sulfonamides and Activated Sulfonate Esters from Sulfonic Acids

A general new method for the preparation of sulfonamides and activated sulfonate esters by the direct coupling of sulfonic acid salts with amines and alcohols using the reagent triphenylphosphine ditriflate is described. A new reusable polymer-supported reagent for these transformations under hetero...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of the American Chemical Society 2004-02, Vol.126 (4), p.1024-1025
Hauptverfasser: Caddick, Stephen, Wilden, Jonathan D, Judd, Duncan B
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Esters - chemistry
Exact sciences and technology
Mesylates - chemistry
Organic chemistry
Organophosphorus Compounds - chemistry
Sulfonamides - chemical synthesis
Sulfonic Acids - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A general new method for the preparation of sulfonamides and activated sulfonate esters by the direct coupling of sulfonic acid salts with amines and alcohols using the reagent triphenylphosphine ditriflate is described. A new reusable polymer-supported reagent for these transformations under heterogeneous conditions is also described. These methods provide a fundamentally new approach to making small molecules containing the sulfonamide functional group.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja0397658