Dietary NaCl Regulates Renal Aminopeptidase N: Relevance to Hypertension in the Dahl Rat

ABSTRACT—Aminopeptidase N (APN) is an abundant metallohydrolase in the brush border of kidney proximal tubule cells that degrades angiotensin III (Ang III) to angiotensin IV (Ang IV) and, along with dipeptidylaminopeptidase, degrades Ang IV. We examined the impact of a high-salt diet on renal APN ac...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2004-02, Vol.43 (2), p.282-285
Hauptverfasser:	Farjah, Mariam, Washington, Theressia L, Roxas, Bryan P, Geenen, David L, Danziger, Robert S
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system CD13 Antigens - genetics CD13 Antigens - metabolism Chromosome Mapping Clinical manifestations. Epidemiology. Investigative techniques. Etiology Experimental diseases Hypertension - enzymology Hypertension - genetics Kidney - enzymology Male Medical sciences Rats Rats, Inbred Dahl Rats, Inbred Lew Rats, Sprague-Dawley RNA, Messenger - metabolism Sodium Chloride - administration & dosage Sodium Chloride - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	ABSTRACT—Aminopeptidase N (APN) is an abundant metallohydrolase in the brush border of kidney proximal tubule cells that degrades angiotensin III (Ang III) to angiotensin IV (Ang IV) and, along with dipeptidylaminopeptidase, degrades Ang IV. We examined the impact of a high-salt diet on renal APN activity and transcript abundance in the Sprague-Dawley and Dahl salt-sensitive (SS/Jr) rat strains. APN transcript abundance and protein abundance were ≈2-fold greater (P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.HYP.0000111584.15095.8a