Interleukin-6 in the aging brain

Astrocytes, microglia, and neurons express the cytokine interleukin-6 (IL-6), which in the brain has been suggested to reduce food intake, inhibit memory and learning, cause neurodegeneration, and exacerbate sickness behavior induced by other cytokines. Recent evidence indicates IL-6 levels are incr...

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Veröffentlicht in:	Journal of neuroimmunology 2004-02, Vol.147 (1), p.141-144
Hauptverfasser:	Godbout, J.P., Johnson, R.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Aging Aging - metabolism Animals Binding Sites Brain Brain - cytology Brain - metabolism Brain Chemistry Cells, Cultured Cytokines Humans Interleukin-6 Interleukin-6 - genetics Interleukin-6 - metabolism Macrophage-1 Antigen - genetics Macrophage-1 Antigen - metabolism Mice Microglia Nerve Degeneration - immunology Neuroglia - metabolism Neurons - metabolism NF-kappa B - metabolism Promoter Regions, Genetic Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - biosynthesis
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Beschreibung
Zusammenfassung:	Astrocytes, microglia, and neurons express the cytokine interleukin-6 (IL-6), which in the brain has been suggested to reduce food intake, inhibit memory and learning, cause neurodegeneration, and exacerbate sickness behavior induced by other cytokines. Recent evidence indicates IL-6 levels are increased in brain of healthy aged animals, thus it may play a role in the neurophysiological manifestations of old age. The purpose of this brief report is to discuss the new evidence that suggests an age-related increase in brain IL-6 and the impact this inflammatory cytokine may have on “successful” aging.
ISSN:	0165-5728 1872-8421
DOI:	10.1016/j.jneuroim.2003.10.031