Adrenalectomy further suppresses the NT-3 mRNA response to traumatic brain injury but this effect is not reversed with corticosterone

Fluid percussion injury (FPI) and in situ hybridisation were used to evaluate the expression of NT-3 mRNA in the hippocampus after traumatic brain injury (TBI) in adrenal-intact and adrenalectomised rats (with or without corticosterone replacement). FPI and adrenalectomy independently significantly...

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Veröffentlicht in:	Brain research. Molecular brain research. 2004-01, Vol.120 (2), p.188-192
Hauptverfasser:	Grundy, Paul L., Patel, Nitin, Harbuz, Michael S., Lightman, Stafford L., Sharples, Peta M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenalectomy Analysis of Variance Animals Autoradiography - methods Biological and medical sciences Brain Injuries - drug therapy Brain Injuries - genetics Brain Injuries - metabolism Corticosterone - pharmacology Corticosterone - therapeutic use Disease Models, Animal Dose-Response Relationship, Drug Fluid percussion injury Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Glucocorticoid Hippocampus Hippocampus - drug effects Hippocampus - metabolism In Situ Hybridization Injuries of the nervous system and the skull. Diseases due to physical agents Male Medical sciences Neurotrophic factor Neurotrophin 3 - genetics Neurotrophin 3 - metabolism NT-3 Percussion - adverse effects Rats Rats, Wistar RNA, Messenger - metabolism Traumas. Diseases due to physical agents Traumatic brain injury Vertebrates: nervous system and sense organs
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Zusammenfassung:	Fluid percussion injury (FPI) and in situ hybridisation were used to evaluate the expression of NT-3 mRNA in the hippocampus after traumatic brain injury (TBI) in adrenal-intact and adrenalectomised rats (with or without corticosterone replacement). FPI and adrenalectomy independently significantly reduced the expression of NT-3 mRNA in the dentate gyrus (DG) and CA2 region. The effects of adrenalectomy in the CA2 region were partially reversed with corticosterone. In adrenalectomised animals undergoing FPI, a further significant decrease in NT-3 mRNA was observed in the DG, but this was not reversed by corticosterone. Glucocorticoids may, therefore, play a role in the basal regulation of NT-3 in the hippocampus, but the role of glucocorticoids in the modulation of the NT-3 response to TBI is unclear.
ISSN:	0169-328X 1872-6941
DOI:	10.1016/j.molbrainres.2003.09.018