Modular DNA-Programmed Assembly of Linear and Branched Conjugated Nanostructures
A new strategy for self-assembly and covalent coupling of encoded molecular modules into nanostructures with predetermined connectivity has been developed. The method uses DNA-functionalized oligo(phenylene ethynylene)-derived organic modules for controlling the assembly and covalent coupling of mul...
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| Veröffentlicht in: | Journal of the American Chemical Society 2004-02, Vol.126 (4), p.1044-1046 |
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| container_title | Journal of the American Chemical Society |
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| creator | Gothelf, Kurt V Thomsen, Anne Nielsen, Morten Cló, Emiliano Brown, Raymond S |
| description | A new strategy for self-assembly and covalent coupling of encoded molecular modules into nanostructures with predetermined connectivity has been developed. The method uses DNA-functionalized oligo(phenylene ethynylene)-derived organic modules for controlling the assembly and covalent coupling of multiple modules. Rigid linear modules (LM) and tripoidal modules (TM) were functionalized with short oligonucleotides at each terminus. They can hybridize and thereby link up modules containing complementary sequences. Each terminus of the oligo(phenylene ethynylene) modules also consists of a salicylaldehyde moiety, which can form metal−salen complexes with other modules. The salicylaldehyde groups of two modules are brought in proximity when their adjoining DNA sequences are complementary, and they selectively form a manganese−salen complex in the presence of ethylenediamine and manganese acetate. The resulting structures consist of a matrix of linear and branched oligo(phenylene ethynylene)s which are linked by conjugated and rigid manganese−salen complexes. These nanostructures are potential conductors for applications in molecular electronics. |
| doi_str_mv | 10.1021/ja038333u |
| format | Article |
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The method uses DNA-functionalized oligo(phenylene ethynylene)-derived organic modules for controlling the assembly and covalent coupling of multiple modules. Rigid linear modules (LM) and tripoidal modules (TM) were functionalized with short oligonucleotides at each terminus. They can hybridize and thereby link up modules containing complementary sequences. Each terminus of the oligo(phenylene ethynylene) modules also consists of a salicylaldehyde moiety, which can form metal−salen complexes with other modules. The salicylaldehyde groups of two modules are brought in proximity when their adjoining DNA sequences are complementary, and they selectively form a manganese−salen complex in the presence of ethylenediamine and manganese acetate. The resulting structures consist of a matrix of linear and branched oligo(phenylene ethynylene)s which are linked by conjugated and rigid manganese−salen complexes. These nanostructures are potential conductors for applications in molecular electronics.</description><identifier>ISSN: 0002-7863</identifier><identifier>EISSN: 1520-5126</identifier><identifier>DOI: 10.1021/ja038333u</identifier><identifier>PMID: 14746471</identifier><identifier>CODEN: JACSAT</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Acrylic Resins - chemistry ; Aldehydes - chemistry ; Applied sciences ; Biological and medical sciences ; DNA - chemical synthesis ; DNA - chemistry ; Electronics ; Exact sciences and technology ; Fundamental and applied biological sciences. Psychology ; Interactions. Associations ; Intermolecular phenomena ; Models, Molecular ; Molecular biophysics ; Molecular electronics, nanoelectronics ; Nanotechnology - methods ; Oligonucleotides - chemical synthesis ; Oligonucleotides - chemistry ; Semiconductor electronics. Microelectronics. Optoelectronics. Solid state devices</subject><ispartof>Journal of the American Chemical Society, 2004-02, Vol.126 (4), p.1044-1046</ispartof><rights>Copyright © 2004 American Chemical Society</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a410t-81c0aa03c63c9f3da94e9185895d08d97479a45133ebb7c770625ef4be51fc0a3</citedby><cites>FETCH-LOGICAL-a410t-81c0aa03c63c9f3da94e9185895d08d97479a45133ebb7c770625ef4be51fc0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ja038333u$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ja038333u$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15431608$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14746471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gothelf, Kurt V</creatorcontrib><creatorcontrib>Thomsen, Anne</creatorcontrib><creatorcontrib>Nielsen, Morten</creatorcontrib><creatorcontrib>Cló, Emiliano</creatorcontrib><creatorcontrib>Brown, Raymond S</creatorcontrib><title>Modular DNA-Programmed Assembly of Linear and Branched Conjugated Nanostructures</title><title>Journal of the American Chemical Society</title><addtitle>J. Am. Chem. Soc</addtitle><description>A new strategy for self-assembly and covalent coupling of encoded molecular modules into nanostructures with predetermined connectivity has been developed. The method uses DNA-functionalized oligo(phenylene ethynylene)-derived organic modules for controlling the assembly and covalent coupling of multiple modules. Rigid linear modules (LM) and tripoidal modules (TM) were functionalized with short oligonucleotides at each terminus. They can hybridize and thereby link up modules containing complementary sequences. Each terminus of the oligo(phenylene ethynylene) modules also consists of a salicylaldehyde moiety, which can form metal−salen complexes with other modules. The salicylaldehyde groups of two modules are brought in proximity when their adjoining DNA sequences are complementary, and they selectively form a manganese−salen complex in the presence of ethylenediamine and manganese acetate. The resulting structures consist of a matrix of linear and branched oligo(phenylene ethynylene)s which are linked by conjugated and rigid manganese−salen complexes. These nanostructures are potential conductors for applications in molecular electronics.</description><subject>Acrylic Resins - chemistry</subject><subject>Aldehydes - chemistry</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>DNA - chemical synthesis</subject><subject>DNA - chemistry</subject><subject>Electronics</subject><subject>Exact sciences and technology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Interactions. Associations</subject><subject>Intermolecular phenomena</subject><subject>Models, Molecular</subject><subject>Molecular biophysics</subject><subject>Molecular electronics, nanoelectronics</subject><subject>Nanotechnology - methods</subject><subject>Oligonucleotides - chemical synthesis</subject><subject>Oligonucleotides - chemistry</subject><subject>Semiconductor electronics. Microelectronics. Optoelectronics. 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Solid state devices</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gothelf, Kurt V</creatorcontrib><creatorcontrib>Thomsen, Anne</creatorcontrib><creatorcontrib>Nielsen, Morten</creatorcontrib><creatorcontrib>Cló, Emiliano</creatorcontrib><creatorcontrib>Brown, Raymond S</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gothelf, Kurt V</au><au>Thomsen, Anne</au><au>Nielsen, Morten</au><au>Cló, Emiliano</au><au>Brown, Raymond S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modular DNA-Programmed Assembly of Linear and Branched Conjugated Nanostructures</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. Am. Chem. Soc</addtitle><date>2004-02-04</date><risdate>2004</risdate><volume>126</volume><issue>4</issue><spage>1044</spage><epage>1046</epage><pages>1044-1046</pages><issn>0002-7863</issn><eissn>1520-5126</eissn><coden>JACSAT</coden><abstract>A new strategy for self-assembly and covalent coupling of encoded molecular modules into nanostructures with predetermined connectivity has been developed. The method uses DNA-functionalized oligo(phenylene ethynylene)-derived organic modules for controlling the assembly and covalent coupling of multiple modules. Rigid linear modules (LM) and tripoidal modules (TM) were functionalized with short oligonucleotides at each terminus. They can hybridize and thereby link up modules containing complementary sequences. Each terminus of the oligo(phenylene ethynylene) modules also consists of a salicylaldehyde moiety, which can form metal−salen complexes with other modules. The salicylaldehyde groups of two modules are brought in proximity when their adjoining DNA sequences are complementary, and they selectively form a manganese−salen complex in the presence of ethylenediamine and manganese acetate. The resulting structures consist of a matrix of linear and branched oligo(phenylene ethynylene)s which are linked by conjugated and rigid manganese−salen complexes. These nanostructures are potential conductors for applications in molecular electronics.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>14746471</pmid><doi>10.1021/ja038333u</doi><tpages>3</tpages></addata></record> |
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| subjects | Acrylic Resins - chemistry Aldehydes - chemistry Applied sciences Biological and medical sciences DNA - chemical synthesis DNA - chemistry Electronics Exact sciences and technology Fundamental and applied biological sciences. Psychology Interactions. Associations Intermolecular phenomena Models, Molecular Molecular biophysics Molecular electronics, nanoelectronics Nanotechnology - methods Oligonucleotides - chemical synthesis Oligonucleotides - chemistry Semiconductor electronics. Microelectronics. Optoelectronics. Solid state devices |
| title | Modular DNA-Programmed Assembly of Linear and Branched Conjugated Nanostructures |
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