Immunomodulatory constituents from an Ascomycete, Chaetomium seminudum

A screening study focusing on immunomodulatory activity of the EtOAc extract of an Ascomycete, Chaetomium seminudum, has afforded a known epipolythiodioxopiperazine, chetomin (1), together with three new chetomin-related metabolites named chetoseminudins A (2), B (3), and C (4). Among these four met...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2004-01, Vol.67 (1), p.98-102
Hauptverfasser:	Fujimoto, H, Sumino, M, Okuyama, E, Ishibashi, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - chemistry Adjuvants, Immunologic - isolation & purification Adjuvants, Immunologic - pharmacology Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Biological and medical sciences Chaetomium - chemistry Chaetomium seminudum Disulfides General pharmacology Heterocyclic Compounds, 4 or More Rings - chemistry Heterocyclic Compounds, 4 or More Rings - isolation & purification Heterocyclic Compounds, 4 or More Rings - pharmacology Indole Alkaloids Japan Lymphocytes - drug effects Medical sciences Mice Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Spleen - cytology
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Zusammenfassung:	A screening study focusing on immunomodulatory activity of the EtOAc extract of an Ascomycete, Chaetomium seminudum, has afforded a known epipolythiodioxopiperazine, chetomin (1), together with three new chetomin-related metabolites named chetoseminudins A (2), B (3), and C (4). Among these four metabolites, 1 and 2 have been deduced as the immunosuppressive features of this fungus.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0302201