The cannabinoid receptor: biochemical, anatomical and behavioral characterization

The cannabinoid receptor: biochemical, anatomical and behavioral characterization

The actions of the active principle of marihuana, Δ 9-tetrahydrocannabinol, are mimicked by synthetic cannabinoid agonists showing high potency and enantioselectivity in behavioral assays. These drugs have been used to characterize cannabinoid receptor binding, biochemistry and pharmacology, leading...

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Veröffentlicht in:Trends in Neurosciences 1990-10, Vol.13 (10), p.420-423
Hauptverfasser: Howlett, Allyn C, Bidaut-Russell, Michelle, Devane, William A, Melvin, Lawrence S, Johnson, M.Ross, Herkenham, Miles
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Behavior, Animal - drug effects
Brain - metabolism
Cannabinoids - metabolism
Cannabinoids - pharmacology
Humans
Mammalia
Rats
Receptors, Cannabinoid
Receptors, Drug - metabolism
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Zusammenfassung:The actions of the active principle of marihuana, Δ 9-tetrahydrocannabinol, are mimicked by synthetic cannabinoid agonists showing high potency and enantioselectivity in behavioral assays. These drugs have been used to characterize cannabinoid receptor binding, biochemistry and pharmacology, leading to a better understanding of the effects of cannabinoids in the CNS of humans and experimental animals.
ISSN:0166-2236
1878-108X
DOI:10.1016/0166-2236(90)90124-S