Electrochemical determination of oxytetracycline in veterinary drugs

Conductometric, potentiometric and cyclic voltammetric (CV) titration methods are proposed for determination of oxytetracycline (OTC), commonly used in veterinary. The electrochemical titration of OTC hydrochloride with NH 4Mo 7O 24, NaVO 3, NaOH, AgNO 3 and FeCl 3 as titrants are reported. The prop...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2004-01, Vol.34 (1), p.95-102
Hauptverfasser:	Kurzawa, Marzanna, Kowalczyk-Marzec, Agnieszka
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Conductometry Cyclic Electrochemistry - methods Fundamental and applied biological sciences. Psychology General pharmacology Medical sciences Oxytetracycline - analysis Oxytetracycline - chemistry Oxytetracycline hydrochloride Pharmacology. Drug treatments Potentiometry Titrimetric assay Veterinary Drugs - analysis Veterinary Drugs - chemistry Voltammetry
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Beschreibung
Zusammenfassung:	Conductometric, potentiometric and cyclic voltammetric (CV) titration methods are proposed for determination of oxytetracycline (OTC), commonly used in veterinary. The electrochemical titration of OTC hydrochloride with NH 4Mo 7O 24, NaVO 3, NaOH, AgNO 3 and FeCl 3 as titrants are reported. The proposed methods were found to be highly precise, having a relative standard deviation (R.S.D.) below 1.0%. Proposed electrochemical titrations were successfully applied to the assay of commercial preparations: Tetrox, Tetramutin ®OT and Neox, containing the above-mentioned antibiotics. The validity of the methods was tested by the recovery studies of standard addition to pharmaceuticals and results were found to be satisfactory.
ISSN:	0731-7085 1873-264X
DOI:	10.1016/j.japna.2003.08.010