Spirostanol and Furostanol Glycosides from the Fresh Tubers of Polianthes tuberosa

Six new steroid glycosidestwo spirostanols, polianthosides B and C (1, 2), and four furostanols, polianthosides D−G (3−6)were isolated from the fresh tubers of Polianthes tuberosa, together with seven known spirostanols (7−13) and a known furostanol (14) saponins. Their structures were elucidated...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2004-01, Vol.67 (1), p.5-9
Hauptverfasser:	Jin, Jian-Ming, Zhang, Ying-Jun, Yang, Chong-Ren
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Asparagaceae - chemistry Biological and medical sciences Drug Screening Assays, Antitumor General pharmacology Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology HeLa Cells Humans Hydrolysis Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Sterols - chemistry Sterols - isolation & purification Sterols - pharmacology Tumor Cells, Cultured
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Zusammenfassung:	Six new steroid glycosidestwo spirostanols, polianthosides B and C (1, 2), and four furostanols, polianthosides D−G (3−6)were isolated from the fresh tubers of Polianthes tuberosa, together with seven known spirostanols (7−13) and a known furostanol (14) saponins. Their structures were elucidated on the basis of spectroscopic analysis and the results of acidic and enzymatic hydrolysis. The cytotoxic activities of 1−14 against HeLa cells are reported.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np034028a