Synthesis and biological evaluation of (−)-laulimalide analogues

Analogues of the marine natural product (−)-laulimalide were prepared by total synthesis and evaluated in vitro for anticancer activity. Analogues of the marine natural product (−)-laulimalide were prepared by total synthesis and evaluated in vitro for anticancer activity.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-02, Vol.14 (3), p.575-579
Hauptverfasser:	Gallagher, Brian M., Fang, Francis G., Johannes, Charles W., Pesant, Marc, Tremblay, Martin R., Zhao, Hongjuan, Akasaka, Kozo, Li, Xiang-yi, Liu, Junke, Littlefield, Bruce A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Biological and medical sciences Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Division - drug effects Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Female General aspects Humans Macrolides Medical sciences Molecular Structure Pharmacology. Drug treatments Structure-Activity Relationship Taxoids - chemical synthesis Taxoids - chemistry Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	Analogues of the marine natural product (−)-laulimalide were prepared by total synthesis and evaluated in vitro for anticancer activity. Analogues of the marine natural product (−)-laulimalide were prepared by total synthesis and evaluated in vitro for anticancer activity.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2003.12.001