Towards conformationally-locked difluorosugar analogues: an unexpected sense of dihydroxylation

Towards conformationally-locked difluorosugar analogues: an unexpected sense of dihydroxylation

Difluorinated cyclooctenones, synthesised using RCM, can be used as templates for stereoselective oxidative transformations to products that undergo transannular reactions to afford conformationally-locked analogues of 2-deoxy-2,2-difluorosugars with different stereochemical relationships between th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2004-02 (3), p.302-303
Hauptverfasser: Fawcett, John, Griffiths, Gerry A, Percy, Jonathan M, Pintat, Stéphane, Smith, Clive A, Spencer, Neil S, Uneyama, Emi
Format: Artikel
Sprache:eng
Schlagworte:
Carbohydrate Conformation
Cyclization
Deoxy Sugars - chemistry
Fluorine - chemistry
Hydroxylation
Stereoisomerism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Difluorinated cyclooctenones, synthesised using RCM, can be used as templates for stereoselective oxidative transformations to products that undergo transannular reactions to afford conformationally-locked analogues of 2-deoxy-2,2-difluorosugars with different stereochemical relationships between the C-2 and C-3 hydroxyl groups.
ISSN:1359-7345
DOI:10.1039/b313813e