Recombination: Holliday Junction Resolution and Crossover Formation

The heterodimeric nuclease Mus81–Eme1 has been proposed to be a Holliday junction resolvase and has now been found to be responsible for nearly all meiotic crossovers in fission yeast. The intriguing substrate preference of this enzyme for nicked Holliday junctions opens the possibility that crossov...

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Veröffentlicht in:	Current biology 2004-01, Vol.14 (2), p.R56-R58
1. Verfasser:	Heyer, Wolf-Dietrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Crossing Over, Genetic - genetics DNA Damage - genetics DNA Damage - physiology DNA Repair - genetics DNA Repair - physiology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endonucleases Holliday Junction Resolvases - genetics Meiosis - genetics Meiosis - physiology Models, Genetic Saccharomyces cerevisiae Proteins Schizosaccharomyces Schizosaccharomyces pombe
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Zusammenfassung:	The heterodimeric nuclease Mus81–Eme1 has been proposed to be a Holliday junction resolvase and has now been found to be responsible for nearly all meiotic crossovers in fission yeast. The intriguing substrate preference of this enzyme for nicked Holliday junctions opens the possibility that crossover formation may not always involve double Holliday junctions.
ISSN:	0960-9822 1879-0445
DOI:	10.1016/j.cub.2003.12.043