Evaluation of 3H-Paroxetine as a Radioligand for in vivo Study of 5-Hydroxytryptamine Uptake Sites in Mouse Brain

Evaluation of 3H-Paroxetine as a Radioligand for in vivo Study of 5-Hydroxytryptamine Uptake Sites in Mouse Brain

The distribution of radioactivity in the mouse brain after intravenous administration of 3H-paroxetine was in the order (highest to lowest) hypothalamus>cerebral cortex>cerebellum. The radioactivity in the hypothalamus and cerebral cortex after injection of 3H-paroxetine was significantly decr...

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Veröffentlicht in:RADIOISOTOPES 1990/08/15, Vol.39(8), pp.335-341
Hauptverfasser: HASHIMOTO, Kenji, GOROMARU, Tsuyoshi
Format: Artikel
Sprache:eng
Schlagworte:
5-hydroxytryptamine uptake sites
Animals
Binding Sites
Brain - metabolism
Evaluation Studies as Topic
in vivo binding
Injections, Intravenous
Male
Mice
mouse brain
Paroxetine
Piperidines - administration & dosage
Piperidines - pharmacokinetics
Radioligand Assay
Receptors, Serotonin - metabolism
Serotonin Antagonists - administration & dosage
Serotonin Antagonists - pharmacokinetics
Tritium - administration & dosage
tritium-paroxetine
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Zusammenfassung:The distribution of radioactivity in the mouse brain after intravenous administration of 3H-paroxetine was in the order (highest to lowest) hypothalamus>cerebral cortex>cerebellum. The radioactivity in the hypothalamus and cerebral cortex after injection of 3H-paroxetine was significantly decreased by treatment with 6-nitroquipazine or paroxetine. HPLC and TLC analyses show that no radioactive metabolites were found in the mouse brain 3 h after intravenous administration of 3H-paroxetine. The present results indicate that 3H-paroxetine would be a suitable radioligand for in vivo study of 5-HT uptake sites in mouse brain.
ISSN:0033-8303
1884-4111
DOI:10.3769/radioisotopes.39.8_335