Altered N-myc Downstream-Regulated Gene 1 Protein Expression in African-American Compared with Caucasian Prostate Cancer Patients

Purpose: The protein encoded by N-myc downstream-regulated gene 1 ( NDRG1 ) is a recently discovered protein whose transcription is induced by androgens and hypoxia. We hypothesized that NDRG1 expression patterns might reveal a biological basis for the disparity of clinical outcome of prostate cance...

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Veröffentlicht in:Clinical cancer research 2004-01, Vol.10 (1), p.222-227
Hauptverfasser: Caruso, Robert P, Levinson, Benjamin, Melamed, Jonathan, Wieczorek, Rosemary, Taneja, Samir, Polsky, David, Chang, Caroline, Zeleniuch-Jacquotte, Anne, Salnikow, Konstantin, Yee, Herman, Costa, Max, Osman, Iman
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Sprache:eng
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Zusammenfassung:Purpose: The protein encoded by N-myc downstream-regulated gene 1 ( NDRG1 ) is a recently discovered protein whose transcription is induced by androgens and hypoxia. We hypothesized that NDRG1 expression patterns might reveal a biological basis for the disparity of clinical outcome of prostate cancer patients with different ethnic backgrounds. Experimental Design: Patients who underwent radical prostatectomy between 1990 and 2000 at Veterans Administration Medical Center of New York were examined. We studied 223 cases, including 157 African Americans and 66 Caucasians (T2, n = 144; ≥T3, n = 79; Gleason
ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.CCR-0604-3