Effect of Vitamins C and E on cognitive function in mouse
The aim of this study was to verify the role of Vitamins C and E on the cognitive function of young and aged mice. First and second groups of young animals (aged 3 months) received either Vitamin E (250 mg/kg per day) or Vitamin C (300 mg/kg per day) for 60 days. Third group was treated with the com...
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| Veröffentlicht in: | Pharmacological research 2004-03, Vol.49 (3), p.249-252 |
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| creator | Arzi, A. Hemmati, A.A. Razian, A. |
| description | The aim of this study was to verify the role of Vitamins C and E on the cognitive function of young and aged mice. First and second groups of young animals (aged 3 months) received either Vitamin E (250
mg/kg per day) or Vitamin C (300
mg/kg per day) for 60 days. Third group was treated with the combination of Vitamin E (250
mg/kg per day) and Vitamin C (300
mg/kg per day) for 60 days. The control group received only vehicle. The aged animal group (aged 15 months) were treated as the young group. Passive avoidance method was used for the assessment of cognitive function in both young and aged animals. The results indicated a significant improvement in the cognitive function of aged mice while there were no significant changes in young animals. |
| doi_str_mv | 10.1016/j.phrs.2003.10.004 |
| format | Article |
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mg/kg per day) or Vitamin C (300
mg/kg per day) for 60 days. Third group was treated with the combination of Vitamin E (250
mg/kg per day) and Vitamin C (300
mg/kg per day) for 60 days. The control group received only vehicle. The aged animal group (aged 15 months) were treated as the young group. Passive avoidance method was used for the assessment of cognitive function in both young and aged animals. The results indicated a significant improvement in the cognitive function of aged mice while there were no significant changes in young animals.</description><identifier>ISSN: 1043-6618</identifier><identifier>EISSN: 1096-1186</identifier><identifier>DOI: 10.1016/j.phrs.2003.10.004</identifier><identifier>PMID: 14726220</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Aging - drug effects ; Aging - physiology ; Animals ; Ascorbic Acid - pharmacology ; Cognition ; Cognition - drug effects ; Cognition - physiology ; Male ; Mice ; Mouse ; Reaction Time - drug effects ; Reaction Time - physiology ; Step-down latency ; Vitamin C ; Vitamin E ; Vitamin E - pharmacology</subject><ispartof>Pharmacological research, 2004-03, Vol.49 (3), p.249-252</ispartof><rights>2003 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-dccd0e3f8c5870d445891324b88964fdb5214cdb1cb6810cb0a3673be000e9323</citedby><cites>FETCH-LOGICAL-c352t-dccd0e3f8c5870d445891324b88964fdb5214cdb1cb6810cb0a3673be000e9323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.phrs.2003.10.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14726220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arzi, A.</creatorcontrib><creatorcontrib>Hemmati, A.A.</creatorcontrib><creatorcontrib>Razian, A.</creatorcontrib><title>Effect of Vitamins C and E on cognitive function in mouse</title><title>Pharmacological research</title><addtitle>Pharmacol Res</addtitle><description>The aim of this study was to verify the role of Vitamins C and E on the cognitive function of young and aged mice. First and second groups of young animals (aged 3 months) received either Vitamin E (250
mg/kg per day) or Vitamin C (300
mg/kg per day) for 60 days. Third group was treated with the combination of Vitamin E (250
mg/kg per day) and Vitamin C (300
mg/kg per day) for 60 days. The control group received only vehicle. The aged animal group (aged 15 months) were treated as the young group. Passive avoidance method was used for the assessment of cognitive function in both young and aged animals. The results indicated a significant improvement in the cognitive function of aged mice while there were no significant changes in young animals.</description><subject>Aging - drug effects</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Ascorbic Acid - pharmacology</subject><subject>Cognition</subject><subject>Cognition - drug effects</subject><subject>Cognition - physiology</subject><subject>Male</subject><subject>Mice</subject><subject>Mouse</subject><subject>Reaction Time - drug effects</subject><subject>Reaction Time - physiology</subject><subject>Step-down latency</subject><subject>Vitamin C</subject><subject>Vitamin E</subject><subject>Vitamin E - pharmacology</subject><issn>1043-6618</issn><issn>1096-1186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMotlb_gAvJyt3Um8ekGXAjpT6g4Ebdhpk8NKWTqclMwX9vhhbcubqXwzmHez-ErgnMCRBxt5nvvmKaUwCWhTkAP0FTApUoCJHidNw5K4QgcoIuUtoAQMUJnKMJ4QsqKIUpqlbOWd3jzuEP39etDwkvcR0MXuEuYN19Bt_7vcVuCLr3WfIBt92Q7CU6c_U22avjnKH3x9Xb8rlYvz69LB_WhWYl7QujtQHLnNSlXIDhvJQVYZQ3UlaCO9OUlHBtGqIbIQnoBmomFqyx-VpbMcpm6PbQu4vd92BTr1qftN1u62DzHUoCAUEZy0Z6MOrYpRStU7vo2zr-KAJqBKY2agSmRmCjloHl0M2xfWhaa_4iR0LZcH8w2Pzj3tuokvY2aGt8zOCU6fx__b-FPHpa</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Arzi, A.</creator><creator>Hemmati, A.A.</creator><creator>Razian, A.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>Effect of Vitamins C and E on cognitive function in mouse</title><author>Arzi, A. ; Hemmati, A.A. ; Razian, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-dccd0e3f8c5870d445891324b88964fdb5214cdb1cb6810cb0a3673be000e9323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aging - drug effects</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Ascorbic Acid - pharmacology</topic><topic>Cognition</topic><topic>Cognition - drug effects</topic><topic>Cognition - physiology</topic><topic>Male</topic><topic>Mice</topic><topic>Mouse</topic><topic>Reaction Time - drug effects</topic><topic>Reaction Time - physiology</topic><topic>Step-down latency</topic><topic>Vitamin C</topic><topic>Vitamin E</topic><topic>Vitamin E - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arzi, A.</creatorcontrib><creatorcontrib>Hemmati, A.A.</creatorcontrib><creatorcontrib>Razian, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arzi, A.</au><au>Hemmati, A.A.</au><au>Razian, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Vitamins C and E on cognitive function in mouse</atitle><jtitle>Pharmacological research</jtitle><addtitle>Pharmacol Res</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>49</volume><issue>3</issue><spage>249</spage><epage>252</epage><pages>249-252</pages><issn>1043-6618</issn><eissn>1096-1186</eissn><abstract>The aim of this study was to verify the role of Vitamins C and E on the cognitive function of young and aged mice. First and second groups of young animals (aged 3 months) received either Vitamin E (250
mg/kg per day) or Vitamin C (300
mg/kg per day) for 60 days. Third group was treated with the combination of Vitamin E (250
mg/kg per day) and Vitamin C (300
mg/kg per day) for 60 days. The control group received only vehicle. The aged animal group (aged 15 months) were treated as the young group. Passive avoidance method was used for the assessment of cognitive function in both young and aged animals. The results indicated a significant improvement in the cognitive function of aged mice while there were no significant changes in young animals.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>14726220</pmid><doi>10.1016/j.phrs.2003.10.004</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1043-6618 |
| ispartof | Pharmacological research, 2004-03, Vol.49 (3), p.249-252 |
| issn | 1043-6618 1096-1186 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aging - drug effects Aging - physiology Animals Ascorbic Acid - pharmacology Cognition Cognition - drug effects Cognition - physiology Male Mice Mouse Reaction Time - drug effects Reaction Time - physiology Step-down latency Vitamin C Vitamin E Vitamin E - pharmacology |
| title | Effect of Vitamins C and E on cognitive function in mouse |
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