Effect of Vitamins C and E on cognitive function in mouse

The aim of this study was to verify the role of Vitamins C and E on the cognitive function of young and aged mice. First and second groups of young animals (aged 3 months) received either Vitamin E (250 mg/kg per day) or Vitamin C (300 mg/kg per day) for 60 days. Third group was treated with the com...

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Veröffentlicht in:	Pharmacological research 2004-03, Vol.49 (3), p.249-252
Hauptverfasser:	Arzi, A., Hemmati, A.A., Razian, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - drug effects Aging - physiology Animals Ascorbic Acid - pharmacology Cognition Cognition - drug effects Cognition - physiology Male Mice Mouse Reaction Time - drug effects Reaction Time - physiology Step-down latency Vitamin C Vitamin E Vitamin E - pharmacology
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Beschreibung
Zusammenfassung:	The aim of this study was to verify the role of Vitamins C and E on the cognitive function of young and aged mice. First and second groups of young animals (aged 3 months) received either Vitamin E (250 mg/kg per day) or Vitamin C (300 mg/kg per day) for 60 days. Third group was treated with the combination of Vitamin E (250 mg/kg per day) and Vitamin C (300 mg/kg per day) for 60 days. The control group received only vehicle. The aged animal group (aged 15 months) were treated as the young group. Passive avoidance method was used for the assessment of cognitive function in both young and aged animals. The results indicated a significant improvement in the cognitive function of aged mice while there were no significant changes in young animals.
ISSN:	1043-6618 1096-1186
DOI:	10.1016/j.phrs.2003.10.004