Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis

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Veröffentlicht in:	Journal of medicinal chemistry 1990-11, Vol.33 (11), p.2952-2956
Hauptverfasser:	Karanewsky, D S, Badia, M C, Ciosek, Jr, C P, Robl, J A, Sofia, M J, Simpkins, L M, DeLange, B, Harrity, T W, Biller, S A, Gordon, E M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticholesteremic Agents - chemical synthesis Anticholesteremic Agents - chemistry Anticholesteremic Agents - pharmacology Butyrates - chemical synthesis Butyrates - chemistry Butyrates - pharmacology Cholesterol - biosynthesis Hydroxymethylglutaryl-CoA Reductase Inhibitors Indoles - chemical synthesis Indoles - chemistry Indoles - pharmacology Liver - enzymology Molecular Structure Organophosphorus Compounds - chemical synthesis Organophosphorus Compounds - chemistry Organophosphorus Compounds - pharmacology Rats Structure-Activity Relationship
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