Portal hypertension: return to fetal life to re-attempt differentiation?

We speculate on the final meaning of the alterations that characterize portal hypertensive enteropathy. The similarity of these alterations with certain morphofunctional characteristics of prenatal splanchnic development makes it possible to hypothesize that the dedifferentiation with return to earl...

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Veröffentlicht in:	Medical hypotheses 2004, Vol.62 (1), p.79-81
Hauptverfasser:	Aller, M.A., López, L., Nava, M.P., Arias, J.L., Durán, H.J., Arias, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Differentiation Embryonic and Fetal Development Humans Hypertension, Portal - embryology Hypertension, Portal - pathology Hypertension, Portal - physiopathology Intestines - blood supply Intestines - embryology Intestines - pathology Intestines - physiopathology Liver - blood supply Liver - embryology Liver - pathology Liver - physiopathology Splanchnic Circulation
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Beschreibung
Zusammenfassung:	We speculate on the final meaning of the alterations that characterize portal hypertensive enteropathy. The similarity of these alterations with certain morphofunctional characteristics of prenatal splanchnic development makes it possible to hypothesize that the dedifferentiation with return to early stages of development could constitute a portal hypertension induced pathogenic mechanism.
ISSN:	0306-9877 1532-2777
DOI:	10.1016/S0306-9877(03)00275-5