Multicomponent Reactions Are Accelerated in Water

Multicomponent Reactions Are Accelerated in Water

Two multicomponent reactions, the Ugi and Passerini reactions, are accelerated by the use of aqueous solutions. The rate enhancements compared to those by organic solvents can approach 300-fold. Reactions performed in water offer another advantage that products are often insoluble, permitting direct...

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Veröffentlicht in:Journal of the American Chemical Society 2004-01, Vol.126 (2), p.444-445
Hauptverfasser: Pirrung, Michael C, Sarma, Koushik Das
Format: Artikel
Sprache:eng
Schlagworte:
Carboxylic Acids - chemistry
Chemistry
Chemistry, Organic - methods
Exact sciences and technology
Ketones - chemistry
Kinetics
Lactams - chemical synthesis
Organic chemistry
Solutions
Water - chemistry
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Zusammenfassung:Two multicomponent reactions, the Ugi and Passerini reactions, are accelerated by the use of aqueous solutions. The rate enhancements compared to those by organic solvents can approach 300-fold. Reactions performed in water offer another advantage that products are often insoluble, permitting direct isolation by precipitation. The methods were applied to the preparation of three small combinatorial libraries.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja038583a