GABAA type binding sites on membranes of spermatozoa

GABAA type binding sites on membranes of spermatozoa

The binding of [3H] gamma-aminobutyric acid (GABA) to seminal membranes of swines and rams was examined. Specific, GABA binding was demonstrated in both species, which showed the features of GABAA type receptors. The affinity of binding was similar in both species, whereas the density of seminal GAB...

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Veröffentlicht in:Life sciences (1973) 1990, Vol.47 (13), p.1147-1151
Hauptverfasser: ERDOÊ, S. L, WEKERLE, L
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Binding Sites
Biological and medical sciences
Cell Membrane - metabolism
Fundamental and applied biological sciences. Psychology
gamma-Aminobutyric Acid - metabolism
Male
Mammalian male genital system
Morphology. Physiology
Receptors, GABA-A - metabolism
Sheep
Spermatozoa - metabolism
Swine
Vertebrates: reproduction
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Zusammenfassung:The binding of [3H] gamma-aminobutyric acid (GABA) to seminal membranes of swines and rams was examined. Specific, GABA binding was demonstrated in both species, which showed the features of GABAA type receptors. The affinity of binding was similar in both species, whereas the density of seminal GABA binding sites was 5 times higher in swine. Our findings suggest that GABA may have a direct effect on spermatozoa.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(90)90175-Q