Biphasic effects of ethanol on acetylcholine release in the rat prefrontal cortex

Low doses of ethanol (0.5 g/kg i.p.) increased, while higher doses (1 g/kg i.p.) reduced acetylcholine (ACh) release in the rat prefrontal cortex (PFC). Ethanol (50–300 mM) applied in the nucleus basalis through a second dialysis probe caused concentration-dependent biphasic changes in prefrontocort...

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Veröffentlicht in:	Brain research 2004-01, Vol.997 (1), p.128-132
Hauptverfasser:	Stancampiano, Roberto, Carta, Manolo, Cocco, Stefania, Curreli, Rita, Rossetti, Zvani Luigi, Fadda, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism ACh release Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Central Nervous System Depressants - pharmacology Dialysis Dose-Response Relationship, Drug Drug Administration Routes Ethanol Ethanol - pharmacology Male Medical sciences Microdialysis Nucleus basalis Prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Rats Rats, Sprague-Dawley Time Factors Toxicology Working memory
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