Biphasic effects of ethanol on acetylcholine release in the rat prefrontal cortex

Low doses of ethanol (0.5 g/kg i.p.) increased, while higher doses (1 g/kg i.p.) reduced acetylcholine (ACh) release in the rat prefrontal cortex (PFC). Ethanol (50–300 mM) applied in the nucleus basalis through a second dialysis probe caused concentration-dependent biphasic changes in prefrontocort...

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Veröffentlicht in:	Brain research 2004-01, Vol.997 (1), p.128-132
Hauptverfasser:	Stancampiano, Roberto, Carta, Manolo, Cocco, Stefania, Curreli, Rita, Rossetti, Zvani Luigi, Fadda, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism ACh release Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Central Nervous System Depressants - pharmacology Dialysis Dose-Response Relationship, Drug Drug Administration Routes Ethanol Ethanol - pharmacology Male Medical sciences Microdialysis Nucleus basalis Prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Rats Rats, Sprague-Dawley Time Factors Toxicology Working memory
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Zusammenfassung:	Low doses of ethanol (0.5 g/kg i.p.) increased, while higher doses (1 g/kg i.p.) reduced acetylcholine (ACh) release in the rat prefrontal cortex (PFC). Ethanol (50–300 mM) applied in the nucleus basalis through a second dialysis probe caused concentration-dependent biphasic changes in prefrontocortical ACh release. Ethanol apparently acts on cholinergic fibers to modulate ACh transmission in the PFC. These results could be of relevance for the bidirectional modulation of working memory by ethanol.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2003.09.078