TNF-alpha induces changes in LDH isotype profile following triggering of apoptosis in PBL of non-Hodgkin's lymphomas

Based on the possibility of tumor necrosis factor (TNF)-alpha to perform multiple and opposite biologic effects, we simultaneously investigated in vitro its effects on intracellular lactate dehydrogenase (LDH)-H and LDH-M isoenzyme activity and morphological characteristics following induction of ap...

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Veröffentlicht in:	Annals of hematology 2004-02, Vol.83 (2), p.84-91
Hauptverfasser:	Jurisic, V, Bumbasirevic, V, Konjevic, G, Djuricic, B, Spuzic, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - physiology Cells, Cultured Female Humans Isoenzymes - metabolism L-Lactate Dehydrogenase - metabolism Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - enzymology Lymphoma, Non-Hodgkin - blood Lymphoma, Non-Hodgkin - drug therapy Lymphoma, Non-Hodgkin - enzymology Male Middle Aged Neoplasm Staging Tumor Necrosis Factor-alpha - pharmacology
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Zusammenfassung:	Based on the possibility of tumor necrosis factor (TNF)-alpha to perform multiple and opposite biologic effects, we simultaneously investigated in vitro its effects on intracellular lactate dehydrogenase (LDH)-H and LDH-M isoenzyme activity and morphological characteristics following induction of apoptosis in peripheral blood mononuclear cells (PBMC) of non-Hodgkin's lymphoma patients (NHL) prior to and after the end of applied chemotherapy. TNF-alpha showed a significant increase ( p
ISSN:	0939-5555
DOI:	10.1007/s00277-003-0731-0