Free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular endothelial cells

ABSTRACT Plasma free fatty acid (FFA) concentrations are increased in states of insulin resistance and impair endothelial function. Because the underlying mechanisms are largely unknown, we examined selected, purified FFAs' (100–300 µmol/l, 24–48 h) action on apoptosis, cell cycle distribution,...

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Veröffentlicht in:	The FASEB journal 2004-01, Vol.18 (1), p.146-148
Hauptverfasser:	Artwohl, Michaela, Roden, Michael, Waldhäusl, Werner, Freudenthaler, Angelika, Baumgartner‐Parzer, Sabina M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis bcl-2 Homologous Antagonist-Killer Protein Cell Cycle - drug effects Cells, Cultured Cyclin-Dependent Kinase Inhibitor p21 Cyclins - metabolism diabetes endothelial dysfunction Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Fatty Acids, Nonesterified - pharmacology Humans Linoleic Acids, Conjugated - pharmacology Membrane Proteins - metabolism vascular complications
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Zusammenfassung:	ABSTRACT Plasma free fatty acid (FFA) concentrations are increased in states of insulin resistance and impair endothelial function. Because the underlying mechanisms are largely unknown, we examined selected, purified FFAs' (100–300 µmol/l, 24–48 h) action on apoptosis, cell cycle distribution, and associated gene/protein expression in human umbilical vein endothelial cells (HUVECs). Stearic acid, but not oleic acid, time and concentration dependently increased endothelial apoptosis by fivefold (n=6, P
ISSN:	0892-6638 1530-6860
DOI:	10.1096/fj.03-0301fje