Synthesis of Hexahydropyridazine-3-phosphonic Acid

The synthesis of hexahydropyridazine-3-phosphonic acid (piperidazine-3-phosphonic acid) was performed via a hetero-Diels-Alder reaction followed by Lewis acid-catalyzed phosphonylation. This two-step procedure was improved to a one-pot reaction.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2004, Vol.52(1), pp.160-162
Hauptverfasser:	Kaname, Mamoru, Yoshinaga, Kazuo, Arakawa, Yasushi, Yoshifuji, Shigeyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis hetero-Diels-Alder reaction hexahydropyridazine-3-phosphonic acid Indicators and Reagents Magnetic Resonance Spectroscopy Mass Spectrometry one-pot reaction Organophosphonates - chemical synthesis Organophosphonates - chemistry phosphonylation piperidazine-3-phosphonic acid Pyridazines - chemistry Spectrophotometry, Infrared α-hydrazinophosphonic acid
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Beschreibung
Zusammenfassung:	The synthesis of hexahydropyridazine-3-phosphonic acid (piperidazine-3-phosphonic acid) was performed via a hetero-Diels-Alder reaction followed by Lewis acid-catalyzed phosphonylation. This two-step procedure was improved to a one-pot reaction.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.52.160