Circulating Human Immunodeficiency Virus (HIV) p24 Antigen-Positive Lymphocytes: A Flow Cytometric Measure of HIV Infection

Asymptomatic individuals seropositive for human immunodeficiency virus (HIV) progress in a heterogeneous fashion toward AIDS. To facilitate monitoring of disease progression and response to therapy, a rapid, new flow cytometric assay (FCA) lymphocyte p24-FCA, has_ been devised to quantify peripheral...

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Veröffentlicht in:	The Journal of infectious diseases 1990-11, Vol.162 (5), p.1018-1024
Hauptverfasser:	Ohlsson-Wilhelm, Betsy M., Cory, Joan M., Kessler, Harold A., Eyster, M. Elaine, Rapp, Fred, Landay, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS AIDS/HIV Antibodies Antigens Biological and medical sciences Blood CD4-Positive T-Lymphocytes Flow Cytometry Fluorescence Fundamental and applied biological sciences. Psychology Gene Products, gag - analysis HIV HIV 1 HIV Antigens - analysis HIV Core Protein p24 HIV Infections - diagnosis HIV Infections - drug therapy HIV Infections - immunology HIV-1 - immunology Homosexuality Humans Infections Leukocyte Count Leukocytes Lymphocytes Lymphocytes - immunology Major Articles Male Microbiology Techniques used in virology Viral Core Proteins - analysis Virology Zidovudine - therapeutic use
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Zusammenfassung:	Asymptomatic individuals seropositive for human immunodeficiency virus (HIV) progress in a heterogeneous fashion toward AIDS. To facilitate monitoring of disease progression and response to therapy, a rapid, new flow cytometric assay (FCA) lymphocyte p24-FCA, has_ been devised to quantify peripheral blood lymphocytes expressing cell-associated HIV-l p24 antigen. Results from 55 asymptomatic, HIV-1-seropositive, serum p~4 antigen-negative individuals ranged from undetectable (
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/162.5.1018